ArticleMolecular medicine reports2017
B(a)P adduct levels and fertility: A cross‑sectional study in a Sicilian population.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 30 citations in OpenAlex.
- Article
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- In-Vitro Effects of Perfluorooctanoic Acid on Human Sperm Function: What Are the Clinical Consequences?Journal of clinical medicine · 2024Article
- Benzo[a]pyrene disrupts LH/hCG-dependent mouse Leydig cell steroidogenesis through receptor/Gαs protein targeting.Scientific reports · 2024Article
- Effects of Benzo[a]pyrene on Human Sperm Functions: An In Vitro Study.International journal of molecular sciences · 2023Article
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- Endocrine-Disrupting Air Pollutants and Their Effects on the Hypothalamus-Pituitary-Gonadal Axis.International journal of molecular sciences · 2020Review
- Tire waste management system in Cyprus in the framework of circular economy strategy.Environmental science and pollution research international · 2019Article
- Decreased total sperm counts in habitants of highly polluted areas of Eastern Sicily, Italy.Environmental science and pollution research international · 2019Article
- Environment and Male Fertility: Effects of Benzo-α-Pyrene and Resveratrol on Human Sperm Function In Vitro.Journal of clinical medicine · 2019Article
- Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review.International journal of environmental research and public health · 2019Review
- Healthy Design and Urban Planning Strategies, Actions, and Policy to Achieve Salutogenic Cities.International journal of environmental research and public health · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benzo(a)pyrene (BaP) is a carcinogenic polycyclic aromatic hydrocarbon for human tissues. Still today it is not fully investigated if BaP can affect negatively the male fertility through the BaP‑DNA adducts production. In the present study, BaP Tetrol I‑1 (TI‑1) and BaP Tetrol II‑2 (TII‑2) BaP‑DNA adducts were investigated in spermatozoa of a Sicilian male population. Semen samples from 86 volunteers in two eastern Sicilian cities (Regalbuto and Melilli) were collected. The quality of semen was evaluated in all samples according to the World Health Organization (WHO) guidelines. We analyzed BaP‑DNA adducts in extracted sperm cell DNA using the modified high‑performance liquid chromatography‑fluorescence method to detects both Tetrols. Differences between Tetrol levels were assessed by the Wilcoxon signed‑rank test and the Mann‑Whitney U test, as appropriate. Correlation between semen quality parameters and Tetrol concentrations were analyzed using the Spearman's correlation coefficient. Σ(TI‑1+TII‑2) were significantly higher in spermatozoa of volunteers from Regalbuto. Furthermore, a greater dispersion of the levels of adducts was observed in these specimens. TI‑1 adducts were higher than TII‑2 in Melilli samples (95% CI) and TII‑2 were higher than TI‑1 in Regalbuto semen samples (95% CI). A significant inverse correlation between sperm progressive motility and both TI‑1 and TII‑2 adducts was observed. The present study showed that BaP negatively affects male fertility by TI‑1 and TII‑2 DNA‑adduct production. These results suggest that DNA adducts could be used as biomarker to assess BaP exposure by air pollution. Further studies are needed to confirm if these findings could affect male fertility because of the growing impairment of this function observed in recent years.
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