ArticleScientific reports2017
Albino T-DNA tomato mutant reveals a key function of 1-deoxy-D-xylulose-5-phosphate synthase (DXS1) in plant development and survival.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 33 citations in OpenAlex.
- Tomato Leaf Color Diversity as a Functional Trait: Molecular Mechanisms, Physiological Significance, and Environmental Responses.International journal of molecular sciences · 2026Review
- Family alliances feeding the carotenoid pathway in tomato.Journal of experimental botany · 2025Review
- Biosynthetic Machinery to Abiotic Stress-Driven Emission: Decoding Multilayer Regulation of Volatile Terpenoids in Plants.Antioxidants (Basel, Switzerland) · 2025Review
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- Proteome and Metabolome Analyses of Albino Bracts inPlants (Basel, Switzerland) · 2025Article
- Exploring the Deoxy-D-xylulose-5-phosphate Synthase Gene Family in Tomato (Plants (Basel, Switzerland) · 2023Article
- Insights into the physiological, molecular, and genetic regulators of albinism inFrontiers in genetics · 2023Article
- Article
- Population-specific, recent positive selection signatures in cultivated Cucumis sativus L. (cucumber).G3 (Bethesda, Md.) · 2022Article
- Cytological, genetic and transcriptomic characterization of a cucumber albino mutant.Frontiers in plant science · 2022Article
- Exon skipping inFrontiers in plant science · 2022Article
- The Genetic Basis of Tomato Aroma.Genes · 2021Review
- Transformation of Long-Lived AlbinoFrontiers in plant science · 2021Article
- The Genetic Components of a Natural Color Palette: A Comprehensive List of Carotenoid Pathway Mutations in Plants.Frontiers in plant science · 2021Review
- Functional Characterization of theFrontiers in plant science · 2020Article
- The TomatoFrontiers in plant science · 2020Article
- Phenotypic and genetic characterization of tomato mutants provides new insights into leaf development and its relationship to agronomic traits.BMC plant biology · 2019Article
- Dissection of Chemical Composition and Associated Gene Expression in the Pigment-Deficient Tea Cultivar 'Xiaoxueya' Reveals an Albino Phenotype and Metabolite Formation.Frontiers in plant science · 2019Article
- Review
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11 authors at 3 institutions in 1 country.
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Abstract
Photosynthetic activity is indispensable for plant growth and survival and it depends on the synthesis of plastidial isoprenoids as chlorophylls and carotenoids. In the non-mevalonate pathway (MEP), the 1-deoxy-D-xylulose-5-phosphate synthase 1 (DXS1) enzyme has been postulated to catalyze the rate-limiting step in the formation of plastidial isoprenoids. In tomato, the function of DXS1 has only been studied in fruits, and hence its functional relevance during plant development remains unknown. Here we report the characterization of the wls-2297 tomato mutant, whose severe deficiency in chlorophylls and carotenoids promotes an albino phenotype. Additionally, growth of mutant seedlings was arrested without developing vegetative organs, which resulted in premature lethality. Gene cloning and silencing experiments revealed that the phenotype of wls-2297 mutant was caused by 38.6 kb-deletion promoted by a single T-DNA insertion affecting the DXS1 gene. This was corroborated by in vivo and molecular complementation assays, which allowed the rescue of mutant phenotype. Further characterization of tomato plants overexpressing DXS1 and comparative expression analysis indicate that DXS1 may play other important roles besides to that proposed during fruit carotenoid biosynthesis. Taken together, these results demonstrate that DXS1 is essentially required for the development and survival of tomato plants.
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