Evidence map›Paper›PMID 28349954›Full record

ArticleScientific reports2017

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury.

Haolu Wang, Run Zhang, Kim R Bridle, Aparna Jayachandran, James A Thomas, Wenzhu Zhang, Jingli Yuan, Zhi Ping Xu, Darrell H G Crawford, Xiaowen Liang and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Oxidative Stress and Age-Related Tumors.Antioxidants (Basel, Switzerland) · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. AnBio-protocol · 2020
    Article
  13. Article
  14. Article
  15. The role of cellular reactive oxygen species in cancer chemotherapy.Journal of experimental & clinical cancer research : CR · 2018
    Review
  16. Article
  17. Ferroptosis and Brain Injury.Developmental neuroscience · 2018
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Haolu WangTherapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia.
Run ZhangAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
Kim R BridleSchool of Medicine, The University of Queensland, Gallipoli Medical Research Institute, Greenslopes Private Hospital, Greenslopes, QLD 4120, Australia.
Aparna JayachandranSchool of Medicine, The University of Queensland, Gallipoli Medical Research Institute, Greenslopes Private Hospital, Greenslopes, QLD 4120, Australia.
James A ThomasDepartment of Gastroenterology, The Prince Charles Hospital, School of Medicine, The University of Queensland, Chermside, QLD 4032, Australia.
Wenzhu ZhangState Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian, 116024, China.
Jingli YuanState Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian, 116024, China.
Zhi Ping XuAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, QLD 4072, Australia.
Darrell H G CrawfordSchool of Medicine, The University of Queensland, Gallipoli Medical Research Institute, Greenslopes Private Hospital, Greenslopes, QLD 4120, Australia.
Xiaowen LiangTherapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia.
Xin LiuTherapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia.
Michael S RobertsTherapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia.
The University of Queensland · AUGallipoli Medical Research Foundation · AUDalian University · CNDalian University of Technology · CNGreenslopes Private Hospital · AUShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress reflects an imbalance between reactive oxygen species (ROS) and antioxidants, which has been reported as an early unifying event in the development and progression of various diseases and as a direct and mechanistic indicator of treatment response. However, highly reactive and short-lived nature of ROS and antioxidant limited conventional detection agents, which are influenced by many interfering factors. Here, we present a two-photon sensing platform for in vivo dual imaging of oxidative stress at the single cell-level resolution. This sensing platform consists of three probes, which combine the turn-on fluorescent transition-metal complex with different specific responsive groups for glutathione (GSH), hydrogen peroxide (H

Indexed as

Oxidative StressAcetaminophenAnimalsCell LineChemical and Drug Induced Liver InjuryCoordination ComplexesDisease Models, AnimalFluorescent DyesGlutathioneHydrogen PeroxideHypochlorous AcidLiverMaleMiceMice, Inbred BALB CMicroscopy, Fluorescence, MultiphotonAcetaminophenCoordination ComplexesFluorescent DyesGlutathioneHydrogen PeroxideHypochlorous AcidReactive Oxygen SpeciesRuthenium

Identifiers

PMID28349954
PMCPMC5368978
OpenAlexW2600906604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.