Evidence map›Paper›PMID 28349755›Full record

ReviewAnnals of the Royal College of Surgeons of England2017

Radical prostatectomy for locally advanced and metastatic prostate cancer.

R Veeratterapillay, S S Goonewardene, J Barclay, R Persad, C Bach

Abstract readReview
In one paragraph

Review in Annals of the Royal College of Surgeons of England, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R VeeratterapillayNewcastle upon Tyne Hospitals NHS Foundation Trust , UK.
S S GoonewardeneGuy's and St Thomas' NHS Foundation Trust , UK.
J BarclayNewcastle upon Tyne Hospitals NHS Foundation Trust , UK.
R PersadNorth Bristol NHS Trust , UK.
C BachNewcastle upon Tyne Hospitals NHS Foundation Trust , UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of advanced prostate cancer remains challenging. Traditionally, radical prostatectomy was discouraged in patients with locally advanced or node positive disease owing to the increased complication rate and treatment related morbidity. However, technical advances and refinements in surgical techniques have enabled the outcomes for patients with high risk prostate cancer to be improved. More recently, the concept of cytoreductive prostatectomy has been described where surgery (often Combined with an extended lymph node dissection) is performed in the setting of metastatic disease. Indirect evidence suggests an advantage using the cytoreductive approach. Hypothetical explanations for this observed benefit include decreased tumour burden, immune modulation, improved response to secondary treatment and avoidance of secondary complications attributable to local tumour growth. Nevertheless, prospective trials are required to investigate this further.

Indexed as

Cytoreduction Surgical ProceduresProstatectomyHumansLymphatic MetastasisLymph Node ExcisionLymph NodesMaleNeoplasm MetastasisProstatic NeoplasmsCytoreductive surgeryRadical prostatectomySurvival

Identifiers

PMID28349755
PMCPMC5449684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.