ArticleObesity (Silver Spring, Md.)2017
Steeper change in body mass across four decades predicts poorer cardiometabolic outcomes at midlife.
Article in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Impact of growth markers and patterns of growth on children's cardiometabolic health: a life course perspective.World journal of pediatrics : WJP · 2026Article
- Lifetime Exposure to Violence and Early Cardiometabolic Risk Factors in a Healthy Swedish Cohort.Journal of the American Heart Association · 2025Article
- Article
- Obesity and Gray Matter Volume Assessed by Neuroimaging: A Systematic Review.Brain sciences · 2021Review
- Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK.BMC public health · 2021Article
- BMI Trajectories from Birth to 23 Years by Cardiometabolic Risks in Young Adulthood.Obesity (Silver Spring, Md.) · 2020Article
- Distinct developmental trajectories of body mass index and diabetes risk: A 5-year longitudinal study of Chinese adults.Journal of diabetes investigation · 2020Article
- Body mass trajectories and cortical thickness in middle-aged men: a 42-year longitudinal study starting in young adulthood.Neurobiology of aging · 2019Article
- Obesity genetics and cardiometabolic health: Potential for risk prediction.Diabetes, obesity & metabolism · 2019Review
- Diet and physical activity as possible mediators of the association between educational attainment and body mass index gain among Australian adults.International journal of public health · 2018Article
- Genetic Underpinnings of Increased BMI and Its Association With Late Midlife Cognitive Abilities.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 2 countries.
Funding
Abstract
objectiveThis study examined patterns of change in adiposity across four decades starting in young adulthood as well as associations between change and midlife cardiometabolic outcomes.
methodsBMI was assessed at ages 20, 40, 56, and 62 years in 977 male veterans from the Vietnam Era Twin Study of Aging. Age 62 (range 56-66) cardiometabolic outcomes included hypertension, diabetes, dyslipidemia, inflammation, and ischemic heart disease. Analyses included latent growth modeling (LGM), latent class growth modeling (LCGM), and logistic regression models.
resultsLinear BMI slope was associated with all outcomes. Accelerated (quadratic) BMI slope was significantly associated with greater risk for hypertension, diabetes, dyslipidemia, and inflammation; odds ratios ranged from 1.93 (diabetes) to 3.15 (dyslipidemia). Initial BMI did not predict later outcomes. Linear slope contributed significant unique variance for diabetes and dyslipidemia even controlling for age 62 BMI. LCGM revealed three trajectories. Men with the relatively stable, lower BMI trajectory had significantly better outcomes than those with trajectories with accelerated increases, especially those including obesity.
conclusionsHow individuals reach late-midlife BMI is important. Steepness of BMI change across 40 years from young adulthood to late midlife, in addition to late-midlife BMI itself, was robustly associated with greater risk for poor cardiometabolic outcomes.
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