ArticleThe Laryngoscope2017
Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model.
Article in The Laryngoscope, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Applications of Electrospinning for Tissue Engineering in Otolaryngology.The Annals of otology, rhinology, and laryngology · 2021Pooled it
- Tissue engineering applications in otolaryngology-The state of translation.Laryngoscope investigative otolaryngology · 2020Review
- Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2019Article
- Electrospun scaffolds limit the regenerative potential of the airway epithelium.Laryngoscope investigative otolaryngology · 2019Article
- Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds.The Annals of otology, rhinology, and laryngology · 2019Article
- Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation.International journal of pediatric otorhinolaryngology · 2019Article
- Quantification of tissue-engineered trachea performance with computational fluid dynamics.The Laryngoscope · 2018Article
- Autologous Cell Seeding in Tracheal Tissue Engineering.Current stem cell reports · 2017Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the safety and efficacy of bronchoscopic interventions in the management of tissue-engineered tracheal graft (TETG) stenosis. STUDY
designAnimal research study.
methodsTETGs were constructed with seeded autologous bone marrow-derived mononuclear cells on a bioartificial graft. Eight sheep underwent tracheal resection and orthotopic implantation of this construct. Animals were monitored by bronchoscopy and fluoroscopy at 3 weeks, 6 weeks, 3 months, and 4 months. Bronchoscopic interventions, including dilation and stenting, were performed to manage graft stenosis. Postdilation measurements were obtained endoscopically and fluoroscopically.
resultsSeven dilations were performed in six animals. At the point of maximal stenosis, the lumen measured 44.6 ± 8.4 mm
conclusionDilation has limited efficacy for managing TETG stenosis, whereas stenting has a more lasting clinical effect. LEVEL OF EVIDENCE: NA. Laryngoscope, 127:2219-2224, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.