Evidence map›Paper›PMID 28349497›Full record

ArticleMedical oncology (Northwood, London, England)2017

Alternative Chk1-independent S/M checkpoint in somatic cells that prevents premature mitotic entry.

Doaa Hussein Zineldeen, Noha Mohamed Shafik, Sheng Fan Li

Abstract read
PubMed Publisher
In one paragraph

Article in Medical oncology (Northwood, London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Doaa Hussein ZineldeenDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Tanta University, El-Geish Street, Tanta, El-Gharbia, Egypt. Zineldeen@gmail.com.
Noha Mohamed ShafikDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Tanta University, El-Geish Street, Tanta, El-Gharbia, Egypt.
Sheng Fan LiAffiliated Zhongshan Hospital, Dalian University, Dalian, China.
Tanta University · EGNagoya City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic instability is the hallmark of cancer. Checkpoint kinase-1 (Chk1) is required for cell cycle delay after DNA damage or blocked DNA replication. Chk1-depleted tumor cells undergo premature mitosis and apoptosis. Here we analyzed the depletion of Chk1 in normal somatic cells in the absence of DNA damage in order to investigate alternative cell cycle checkpoint mechanism(s). By means of adenoviruses, flow cytometry, immunofluorescence and Western blotting, Chk1-depleted mouse embryonic fibroblasts (MEFs) were investigated. Chk1

Indexed as

AnimalsCDC2 Protein KinaseCheckpoint Kinase 1Cyclin B1FibroblastsHistonesMiceMitosisM Phase Cell Cycle CheckpointsS Phase Cell Cycle CheckpointsCcnb1 protein, mouseCDC2 Protein KinaseCheckpoint Kinase 1Chek1 protein, mouseCyclin B1gamma-H2AX protein, mouseHistonesChk1Cyclin B1Premature mitosisS/M checkpointγH2AX

Identifiers

PMID28349497
OpenAlexW2602252491

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.