Evidence map›Paper›PMID 28349362›Full record

SynthesisEndocrine2017

Androgenetic alopecia: a review.

Francesca Lolli, Francesco Pallotti, Alfredo Rossi, Maria C Fortuna, Gemma Caro, Andrea Lenzi, Andrea Sansone, Francesco Lombardo

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 7 pooled it
22.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 7 syntheses or guidelines pooled it, 496 citations in OpenAlex.

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  8. Trial
  9. Does creatine cause hair loss? A 12-week randomized controlled trial.Journal of the International Society of Sports Nutrition · 2025
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  15. Injections of platelet-rich plasma prepared by automatic blood cell separator combined with topical 5% minoxidil in the treatment of male androgenetic alopecia.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
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  20. Scalp Biopsies for Alopecia.Dermatopathology (Basel, Switzerland) · 2026
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168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Francesca LolliDepartment of Experimental Medicine, University of Rome "La Sapienza", Rome, Italy.
Francesco PallottiDepartment of Experimental Medicine, University of Rome "La Sapienza", Rome, Italy.
Alfredo RossiDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy.
Maria C FortunaDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy.
Gemma CaroDepartment of Internal Medicine and Medical Specialties, University of Rome "La Sapienza", Rome, Italy.
Andrea LenziDepartment of Experimental Medicine, University of Rome "La Sapienza", Rome, Italy.
Andrea SansoneDepartment of Experimental Medicine, University of Rome "La Sapienza", Rome, Italy.
Francesco LombardoDepartment of Experimental Medicine, University of Rome "La Sapienza", Rome, Italy. francesco.lombardo@uniroma1.it.
Sapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAndrogenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism of androgenetic alopecia.

methodsUsing the PubMed database, we conducted a systematic review of the literature, selecting studies published from 1916 to 2016.

resultsThe occurrence and development of androgenetic alopecia depends on the interaction of endocrine factors and genetic predisposition. Androgenetic alopecia is characterized by progressive hair follicular miniaturization, caused by the actions of androgens on the epithelial cells of genetically susceptible hair follicles in androgen-dependent areas. Although the exact pathogenesis of androgenetic alopecia remains to be clarified, research has shown that it is a polygenetic condition. Numerous studies have unequivocally identified two major genetic risk loci for androgenetic alopecia, on the X-chromosome AR⁄EDA2R locus and the chromosome 20p11 locus.

conclusionsCandidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms at different genomic loci are associated with androgenetic alopecia development. A number of genes determine the predisposition for androgenetic alopecia in a polygenic fashion. However, further studies are needed before the specific genetic factors of this polygenic condition can be fully explained.

Indexed as

Genetic Predisposition to DiseaseAlopeciaGenetic LociHumansMalePolymorphism, Single NucleotideReceptors, AndrogenReceptors, AndrogenAGAAGA geneticsAndrogen metabolismAndrogen receptorFinasterideMale pattern baldness

Identifiers

PMID28349362
OpenAlexW2597986029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.