Evidence map›Paper›PMID 28349345›Full record

Trial reportLasers in medical science2017

Photodynamic inactivation of Paracoccidioides brasiliensis helps the outcome of oral paracoccidiodomycosis.

Letícia F M Dos Santos, Nathália B Melo, Marina L de Carli, Ana Carolina S C Mendes, Giulia Maria A C Bani, Liana M Verinaud, Eva Burger, Gabriel de Oliveira I Moraes, Alessandro A C Pereira, Maísa R L Brigagão and 2 more

Abstract readCase ReportsClinical Trial
PubMed Publisher
In one paragraph

Trial report in Lasers in medical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Recent Patents on Light-Based Anti-Infective Approaches.Recent patents on anti-infective drug discovery · 2018
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Letícia F M Dos SantosSchool of Dentistry, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Nathália B MeloSchool of Dentistry, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Marina L de CarliDepartment of Clinics and Surgery, School of Dentistry, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Ana Carolina S C MendesDepartment of Microbiology and Immunology, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Giulia Maria A C BaniDepartment of Microbiology and Immunology, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Liana M VerinaudDepartment of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, 13083-865, Brazil.
Eva BurgerDepartment of Microbiology and Immunology, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Gabriel de Oliveira I MoraesDepartment of Biochemistry, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Alessandro A C PereiraDepartment of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil.
Maísa R L BrigagãoDepartment of Biochemistry, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
João Adolfo C HanemannDepartment of Clinics and Surgery, School of Dentistry, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, 37130-000, Brazil.
Felipe F SperandioDepartment of Pathology and Parasitology, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG, Brazil. sperandio@usp.br.
Universidade Federal de Alfenas · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antifungal drug therapy often employed to treat paracoccidiodomycosis (PCM), an important neglected fungal systemic infection, leads to offensive adverse effects, besides being very long-lasting. In addition, PCM compromises the oral health of patients by leading to oral lesions that are very painful and disabling. In that way, photodynamic therapy (PDT) arises as a new promising adjuvant treatment for inactivating Paracoccidioides brasiliensis (Pb), the responsible fungus for PCM, and also for helping the patients to deal with such debilitating oral lesions. PDT has been linked to an improved microbial killing, also presenting the advantage of not inducing immediate microbial resistance such as drugs. For the present study, we investigated the generation of reactive oxygen species (ROS) by using the fluorescent probes hydroxyphenyl fluorescein (HPF) and aminophenyl fluorescein (APF) after toluidine blue (TBO-37.5 mg/L)-mediated PDT (660 nm, 40 mW, and 0.04 cm

Indexed as

PhotochemotherapyAdultAntifungal AgentsFluorescent DyesHumansKineticsMaleMicrobial ViabilityMiddle AgedMouth DiseasesParacoccidioidesParacoccidioidomycosisReactive Oxygen SpeciesTolonium ChlorideAntifungal AgentsFluorescent DyesReactive Oxygen SpeciesTolonium ChlorideParacoccidioidesParacoccidioidomycosisPhotodynamic therapyReactive oxygen speciesToluidine blue

Identifiers

PMID28349345
OpenAlexW2601706237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.