Evidence map›Paper›PMID 28349258›Full record

ArticleBasic research in cardiology2017

Role of bone marrow-derived CD11c

Huan Wang, Dongmin Kwak, John Fassett, Xiaohong Liu, Wu Yao, Xinyu Weng, Xin Xu, Yawei Xu, Robert J Bache, Daniel L Mueller and 1 more

Open access · greenAbstract read
In one paragraph

Article in Basic research in cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Pooled it
  2. Review
  3. Article
  4. Article
  5. CXCL10 Regulates Pressure Overload-Induced Heart Failure.JACC. Basic to translational science · 2026
    Article
  6. PHD2 Deletion in CD8Hypertension (Dallas, Tex. : 1979) · 2025
    Article
  7. Article
  8. IL-22 Attenuates Pressure Overload-Induced Heart Failure and Inflammation.Journal of cardiovascular translational research · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Huan WangCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Dongmin KwakCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
John FassettDepartment of Pharmacology and Toxicology, University of Graz, Graz, Austria.
Xiaohong LiuShanxi Provincial People's Hospital, Taiyuan, China.
Wu YaoCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Xinyu WengDepartment of Cardiology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Xin XuCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Yawei XuDepartment of Cardiology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Robert J BacheCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Daniel L MuellerDivision of Rheumatic and Autoimmune Diseases, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Yingjie ChenCardiovascular Division and Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. chenx106@umn.edu.
University of Minnesota · USShanghai Tenth People's Hospital · CNShaanxi Provincial People's Hospital · CNUniversity of Graz · ATUniversity of Minnesota Medical Center · US

Funding

Multidisciplinary Training in Cardiovascular ResearchT32HL069764 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BACHE, ROBERT JAMES · 2003 to 2013
$2.8M
Mechanisms of Treg and IL-35 in Regulating LV Failure-induced Lung Remodeling and Right Heart HypertrophyR01HL139797 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, YINGJIE · 2018 to 2021
$2.2M
Molecular mechanism of 4E-binding proteins on heart failure developmentR01HL105406 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, YINGJIE · 2011 to 2014
$1.5M
DDAH1 effects on endogenous NOS inhibitors and vascular endothelial functionR21HL098669 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, YINGJIE · 2010 to 2011
$415k
Regulation of the novel mTOR suppressor DDIT4 in the failing heartR21HL098719 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, YINGJIE · 2011 to 2012
$415k
DDAH1 effects on the development of congestive heart failureR21HL102597 · NHLBI · UNIVERSITY OF MINNESOTA · PI CHEN, YINGJIE · 2010 to 2011
$415k
NHLBI NIH HHS R01 HL105406NHLBI NIH HHS R01 HL139797NHLBI NIH HHS R21 HL098669NHLBI NIH HHS R21 HL098719NHLBI NIH HHS R21 HL102597NHLBI NIH HHS T32 HL069764
6 · The paper itself

Abstract

Inflammatory responses play an important role in the development of left ventricular (LV) hypertrophy and dysfunction. Recent studies demonstrated that increased T-cell infiltration and T-cell activation contribute to LV hypertrophy and dysfunction. Dendritic cells (DCs) are professional antigen-presenting cells that orchestrate immune responses, especially by modulating T-cell function. In this study, we investigated the role of bone marrow-derived CD11c

Indexed as

AnimalsAntigen PresentationBone Marrow CellsCardiomegalyCD11c AntigenCD8-Positive T-LymphocytesDendritic CellsDisease Models, AnimalFlow CytometryHypertrophy, Left VentricularLymphocyte ActivationMiceMice, Inbred C57BLMyocarditisVentricular RemodelingCD11c AntigenDendritic cellsFibrosisHypertrophyInflammationLeft ventricle

Identifiers

PMID28349258
PMCPMC6502638
OpenAlexW2602684068

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.