ReviewIntensive care medicine2017
Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future.
Review in Intensive care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07167173 (Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis), which is not on this map. Cited by 105 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictive Model for Multidrug Resistance in Patients Admitted to the Emergency Department With Sepsis
Who cites it
105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 227 citations in OpenAlex.
- Resource use, availability and cost in the provision of critical care in Tanzania: a systematic review.BMJ open · 2022Pooled it
- Global Case-Fatality Rates in Pediatric Severe Sepsis and Septic Shock: A Systematic Review and Meta-analysis.JAMA pediatrics · 2019Pooled it
- The Early Recognition and Management of Sepsis in Sub-Saharan African Adults: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
- Feasibility of establishing a rehabilitation programme in a Vietnamese intensive care unit.PloS one · 2021Trial
- Pulse pressure versus continuous flow monitoring for fluid responsiveness prediction during passive leg raising: a prospective diagnostic accuracy study.BMC anesthesiology · 2026Article
- Evaluation of the implementation of the Critical Care Asia and Africa Intensive Care Unit registry in Ethiopia.World journal of critical care medicine · 2026Article
- Using the 2026 Surviving Sepsis Campaign Guidelines in Practice.Critical care science · 2026Article
- Hemodynamic monitoring in sepsis and septic shock in pediatric patients: a multicenter survey.Critical care science · 2026Article
- Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study.Critical care medicine · 2026Article
- Identification and Characterization of Sepsis Phenotypes in an Indian Cohort.Critical care research and practice · 2026Article
- Predictive validity of the simplified Radiographic Assessment of Lung Edema score for mortality in critically ill patients with COVID-19.Frontiers in medicine · 2026Article
- PD-L1 mediates M1 polarization of macrophages via the AIM2/IL-18/STAT1 signaling axis during sepsis.Cell communication and signaling : CCS · 2025Article
- Lung Involvement in Patients with Leptospirosis in Tropical Australia; Associations, Clinical Course and Implications for Management.Tropical medicine and infectious disease · 2025Article
- Lessons learned from the promotion of Essential Emergency and Critical Care in Tanzania - a qualitative study.BMJ open · 2025Article
- Acute Respiratory Distress Syndrome Definitions in Adults and Children: A Comparative Narrative Review.Journal of clinical medicine · 2025Review
- Adult patients with sepsis in the ICU in Lubumbashi, Democratic Republic of Congo.Critical care (London, England) · 2025Article
- The epidemiology and outcomes of adults with acute hypoxaemic respiratory failure in a low-income country in the context of the COVID-19 pandemic: a prospective, observational, multicentre cohort study.BMJ global health · 2025Observational
- Research Priorities for Noninvasive Sampling of the Lower Respiratory Tract during Acute Respiratory Failure: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2025Article
- The Unmet Critical Care Burden at a Central Hospital in a Resource-Limited Setting: A Point Prevalence Study.World journal of surgery · 2025Article
- Nanomaterials for bacterial enrichment and detection in healthcare.Nanomedicine (London, England) · 2025Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 20 institutions in 17 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome.
aimTo describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics and research aspects of sepsis. We restricted this manuscript to the ICU setting even knowing that many sepsis patients in LMICs are treated outside an ICU.
findingsAlthough many bacterial pathogens causing sepsis in LMICs are similar to those in high-income countries, resistance patterns to antimicrobial drugs can be very different; in addition, causes of sepsis in LMICs often include tropical diseases in which direct damaging effects of pathogens and their products can sometimes be more important than the response of the host. There are substantial and persisting differences in ICU capacities around the world; not surprisingly the lowest capacities are found in LMICs, but with important heterogeneity within individual LMICs. Although many aspects of sepsis management developed in rich countries are applicable in LMICs, implementation requires strong consideration of cost implications and the important differences in resources.
conclusionsAddressing both disease-specific and setting-specific factors is important to improve performance of ICUs in LMICs. Although critical care for severe sepsis is likely cost-effective in LMIC setting, more detailed evaluation at both at a macro- and micro-economy level is necessary. Sepsis management in resource-limited settings is a largely unexplored frontier with important opportunities for research, training, and other initiatives for improvement.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.