ArticleNeurology. Genetics2017
Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study.
Article in Neurology. Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Pooled it
- Pooled it
- Genetic risk of Spontaneous intracerebral hemorrhage: Systematic review and future directions.Journal of the neurological sciences · 2019Pooled it
- Evaluation of functional annotation-informed and ancestry-specific polygenic risk scores for ischemic stroke.Frontiers in bioinformatics · 2026Article
- Ancestry gaps in cardiovascular GWAS: a multi-database review of African representation in genomic studies.Frontiers in genetics · 2025Review
- Alpha globin gene copy number and incident ischemic stroke risk among Black Americans.medRxiv : the preprint server for health sciences · 2023Article
- Ethnodemographic characterization of stroke incidence and burden of disease in hospital discharge records in Ecuador.Frontiers in neurology · 2023Article
- Alpha globin gene copy number and incident ischemic stroke risk among Black Americans.Frontiers in stroke · 2023Article
- A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021Article
- Stroke in Africa: profile, progress, prospects and priorities.Nature reviews. Neurology · 2021Review
- Precision Medicine Approaches to Vascular Disease: JACC Focus Seminar 2/5.Journal of the American College of Cardiology · 2021Review
- Article
- Genetic Contributors of Incident Stroke in 10,700 African Americans With Hypertension: A Meta-Analysis From the Genetics of Hypertension Associated Treatments and Reasons for Geographic and Racial Differences in Stroke Studies.Frontiers in genetics · 2021Article
- Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke.Nature reviews. Neurology · 2020Review
- Heritability for stroke: Essential for taking family history.Caspian journal of internal medicine · 2020Review
- Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study.International journal of stroke : official journal of the International Stroke Society · 2019Article
- Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project.Biopreservation and biobanking · 2018Article
- Polygenic Risk for Depression Increases Risk of Ischemic Stroke: From the Stroke Genetics Network Study.Stroke · 2018Article
- Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities.Journal of the neurological sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDespite epidemiologic data showing an increased stroke incidence in African ancestry populations, genetic studies in this group have so far been limited, and there has been little characterization of the genetic contribution to stroke liability in this population, particularly for stroke subtypes.
methodsWe evaluated the evidence that genetic factors contribute to stroke and stroke subtypes in a population of 917 African and African Caribbean stroke cases and 868 matched controls from London, United Kingdom. We (1) estimated the heritability of stroke in this population using genomic-relatedness matrix-restricted maximum likelihood approaches, (2) assessed loci associated with stroke in Europeans in our population, and (3) evaluated the influence of genetic factors underlying cardiovascular risk factors on stroke using polygenic risk scoring.
resultsOur results indicate a substantial genetic contribution to stroke risk in African ancestry populations (h
conclusionsStroke in African ancestry populations is highly heritable and influenced by genetic determinants underlying cardiovascular risk factors. In addition, stroke loci identified in Europeans share direction of effect in African populations. Future genome-wide association studies must focus on incorporating African ancestry individuals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.