ArticleJournal of exercise rehabilitation2017
Treadmill exercise improves depression-like symptoms by enhancing serotonergic function through upregulation of 5-HT
Article in Journal of exercise rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Antidepressant and Anxiolytic Effects of Intranasal Curcumin in Parkinson's Disease Model Rats: Inhibition of Neuroinflammation and Oxidative Stress.Chinese journal of integrative medicine · 2026Article
- The Olfactory Bulbectomy Model of Depression: Brief History, Current Status and Critique.Brain sciences · 2025Review
- A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters.Behavioral and brain functions : BBF · 2025Review
- Decoding serotonin: the molecular symphony behind depression.Frontiers in cellular neuroscience · 2025Review
- Unveiling the Dominant Factors in Subthalamic Stimulation for Improving Depression in Parkinson's Disease.Movement disorders clinical practice · 2024Article
- Prevalence and lifestyle determinants of depressive symptoms among Chinese children and adolescents.Scientific reports · 2024Article
- Treadmill Exercise Improves Behavioral and Neurobiological Alterations in Restraint-Stressed Rats.Journal of molecular neuroscience : MN · 2023Article
- Olfactory Bulbectomy Model of Depression Lowers Responding for Food in Male and Female Rats: The Modulating Role of Caloric Restriction and Response Requirement.Biomedicines · 2023Article
- Intranasal Administration of Melanin-Concentrating Hormone Reduces Stress-Induced Anxiety- and Depressive-Like Behaviors in Rodents.Experimental neurobiology · 2020Article
- Association between olfactory function and inhibition of emotional competing distractors in major depressive disorder.Scientific reports · 2020Observational
- Effects of sildenafil citrate on peripheral fatigue and exercise performance after exhaustive swimming exercise in rats.Journal of exercise rehabilitation · 2019Article
- Effect of sildenafil citrate on brain central fatigue after exhaustive swimming exercise in rats.Journal of exercise rehabilitation · 2019Article
- Treadmill Exercise Ameliorates Depression-Like Behavior in the Rats With Prenatal Dexamethasone Exposure: The Role of Hippocampal Mitochondria.Frontiers in neuroscience · 2019Article
- Acupuncture modulates stress response by the mTOR signaling pathway in a rat post-traumatic stress disorder model.Scientific reports · 2018Article
- Effect of treadmill exercise on spatial navigation impairment associated with cerebellar Purkinje cell loss following chronic cerebral hypoperfusion.Molecular medicine reports · 2018Article
- Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats.Journal of exercise rehabilitation · 2018Article
- Treadmill exercise alleviates depressive symptoms in rotenone-induced Parkinson disease rats.Journal of exercise rehabilitation · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olfactory bulbectomy (OBX) is a well-known method inducing animal model of depression. Depression is associated with dysfunction of serotonin (5-hydroxytryptamine, 5-HT) system. In the present study, antidepressive effect of treadmill exercise was investigated using olfactory bulbectomized rats. After bilateral bulbectomy, the rats in the treadmill exercise groups were subjected to run on a treadmill for 30 min once a day during 28 days. Increased immobility time and decreased fast time in the forced swim test were observed in the olfactory bulbectomized rats. Sucrose preference in the sucrose preference test was decreased and activity in the open field test was also increased in the olfactory bulbectomized rats. Treadmill exercise decreased immobility time and activity and increased fast time and sucrose preference in the olfactory bulbectomized rats. Expressions of 5-HT and tryptophan hydroxylase (TPH) in the dorsal raphe of rats were suppressed by OBX and treadmill exercise increased the expressions of 5-HT and TPH in the olfactory bulbectomized rats. Serotonin receptor type 1A (5-HT1A) expression in the dorsal raphe was reduced by OBX and treadmill exercise increased 5-HT1A expression in the olfactory bulbectomized rats. In the present study, treadmill exercise ameliorated OBX-induced depressive symptoms. The antidepressive effect of treadmill exercise might be ascribed to the enhancement of serotonergic function through upregulation of 5-HT1A expression in the dorsal raphe.
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