ArticleNeuroImage. Clinical2017
Diffusion imaging of reversible and irreversible microstructural changes within the corticospinal tract in idiopathic normal pressure hydrocephalus.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Cerebral blood flow, autoregulation and vascular reactivity in normal pressure hydrocephalus: a systematic review.Fluids and barriers of the CNS · 2025Pooled it
- Trial
- White matter microstructure alterations in early psychosis and schizophrenia.Translational psychiatry · 2025Article
- Relationship between disproportionately enlarged subarachnoid-space hydrocephalus and white matter tract integrity in normal pressure hydrocephalus.Scientific reports · 2023Article
- Imaging Markers for Normal Pressure Hydrocephalus: An Overview.Biomedicines · 2023Review
- High Periventricular T1 Relaxation Times Predict Gait Improvement After Spinal Tap in Patients with Idiopathic Normal Pressure Hydrocephalus.Clinical neuroradiology · 2022Article
- CSF tap test in idiopathic normal pressure hydrocephalus: still a necessary prognostic test?Journal of neurology · 2022Article
- The Biological Substrate of the Motoric Cognitive Risk Syndrome: A Pilot Study Using Amyloid-/Tau-PET and MR Imaging.Journal of Alzheimer's disease : JAD · 2022Article
- Update on the Cognitive Presentations of iNPH for Clinicians.Frontiers in neurology · 2022Review
- Diffusion Tensor Imaging Profiles Can Distinguish Diffusivity and Neural Properties of White Matter Injury in Hydrocephalus vs. Non-hydrocephalus Using a Strategy of a Periodic Table of DTI Elements.Frontiers in neurology · 2022Article
- Neurobiological underpinnings of rapid white matter plasticity during intensive reading instruction.NeuroImage · 2021Article
- Increased interstitial fluid in periventricular and deep white matter hyperintensities in patients with suspected idiopathic normal pressure hydrocephalus.Scientific reports · 2021Article
- The role of diffusion tensor imaging in idiopathic normal pressure hydrocephalus: A literature review.The neuroradiology journal · 2021Review
- Dynamic functional networks in idiopathic normal pressure hydrocephalus: Alterations and reversibility by CSF tap test.Human brain mapping · 2021Article
- The Spatial Distribution of Water Components with Similar TMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021Article
- DeepACSON automated segmentation of white matter in 3D electron microscopy.Communications biology · 2021Article
- White Matter Microstructural Damage Associated With Gait Abnormalities in Idiopathic Normal Pressure Hydrocephalus.Frontiers in aging neuroscience · 2021Article
- The Pathogenesis Based on the Glymphatic System, Diagnosis, and Treatment of Idiopathic Normal Pressure Hydrocephalus.Clinical interventions in aging · 2021Review
- Ultrasound neuromodulation: mechanisms and the potential of multimodal stimulation for neuronal function assessment.Frontiers in physics · 2020Article
- Automated 3D Axonal Morphometry of White Matter.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The symptoms of idiopathic normal pressure hydrocephalus (iNPH) can be improved by shunt surgery, but prediction of treatment outcome is not established. We investigated changes of the corticospinal tract (CST) in iNPH before and after shunt surgery by using diffusion microstructural imaging, which infers more specific tissue properties than conventional diffusion tensor imaging. Two biophysical models were used: neurite orientation dispersion and density imaging (NODDI) and white matter tract integrity (WMTI). In both methods, the orientational coherence within the CSTs was higher in patients than in controls, and some normalization occurred after the surgery in patients, indicating axon stretching and recovery. The estimated axon density was lower in patients than in controls but remained unchanged after the surgery, suggesting its potential as a marker for irreversible neuronal damage. In a Monte-Carlo simulation that represented model axons as undulating cylinders, both NODDI and WMTI separated the effects of axon density and undulation. Thus, diffusion MRI may distinguish between reversible and irreversible microstructural changes in iNPH. Our findings constitute a step towards a quantitative image biomarker that reflects pathological process and treatment outcomes of iNPH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.