ArticleNeuroImage. Clinical2017
High-dose antidepressants affect near-infrared spectroscopy signals: A retrospective study.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Diagnostic and Predictive Applications of Functional Near-Infrared Spectroscopy for Major Depressive Disorder: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Cognitive and Motor Development in Autistic Children: A Multi-Modal Feasibility Study Combining Neuroimaging and Virtual Reality Paradigms.Brain sciences · 2026Article
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
- The different impacts of functional network centrality and connectivity on the complexity of brain signals in healthy control and first-episode drug-naïve patients with major depressive disorder.Brain imaging and behavior · 2025Article
- Cortical network characteristics in post-stroke anxiety: an fNIRS-based study.Frontiers in neuroscience · 2025Article
- A Naturalistic Prospective Study of the Prognostic Impact of EPHX2 in Major Depressive Disorder: Impulsivity may be an Important Factor.Depression and anxiety · 2025Observational
- The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task.Frontiers in psychiatry · 2023Article
- Increased Prefrontal Activation During Verbal Fluency Task After Repetitive Transcranial Magnetic Stimulation Treatment in Depression: A Functional Near-Infrared Spectroscopy Study.Frontiers in psychiatry · 2022Article
- Unchanged Cognitive Performance and Concurrent Prefrontal Blood Oxygenation After Accelerated Intermittent Theta-Burst Stimulation in Depression: A Sham-Controlled Study.Frontiers in psychiatry · 2021Article
- The Usefulness of Functional Near-Infrared Spectroscopy for the Assessment of Post-Stroke Depression.Frontiers in human neuroscience · 2021Article
- Prefrontal Asymmetry during Cognitive Tasks and its Relationship with Suicide Ideation in Major Depressive Disorder: An fNIRS Study.Diagnostics (Basel, Switzerland) · 2019Article
- Mitochondrial DNA Copy Number Raises the Potential of Left Frontopolar Hemodynamic Response as a Diagnostic Marker for Distinguishing Bipolar Disorder From Major Depressive Disorder.Frontiers in psychiatry · 2019Article
- Gut Microbiota in Bipolar Depression and Its Relationship to Brain Function: An Advanced Exploration.Frontiers in psychiatry · 2019Article
- Reduced Prefrontal Activation During the Tower of London and Verbal Fluency Task in Patients With Bipolar Depression: A Multi-Channel NIRS Study.Frontiers in psychiatry · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have highlighted the clinical usefulness of near-infrared spectroscopy (NIRS) in psychiatry. However, the potential effects of psychotropics on NIRS signals remain unknown.
methodsWe conducted a systematic chart review of 40 depressed patients who underwent NIRS scans during a verbal fluency task to clarify the relationships between psychotropic dosage and NIRS signals. The dosage of psychotropic medications was calculated using defined daily dose (DDD). We investigated the associations between the DDD of psychotropic medications and oxygenated hemoglobin (oxy-Hb) in single channel levels. LIMITATIONS: Retrospective study design and small sample size are the main limitations.
resultsMultiple regression analysis revealed that one channel in the right temporoparietal region had a significant association with antidepressant DDD controlling for age, sex, depression severity, and the DDD of antipsychotics and benzodiazepines. Moreover, high doses of antidepressants had significant effects on NIRS signals compared with low doses, in group comparisons.
conclusionsThe dose-dependent impact of antidepressants on NIRS signals should be taken into account when interpreting NIRS data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.