Evidence map›Paper›PMID 28348952›Full record

ArticleNeuroImage. Clinical2017

Radiation-induced abnormal cortical thickness in patients with nasopharyngeal carcinoma after radiotherapy.

Jiabao Lin, Xiaofei Lv, Meiqi Niu, Lizhi Liu, Jun Chen, Fei Xie, Miao Zhong, Shijun Qiu, Li Li, Ruiwang Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiabao LinCenter for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, PR China.
Xiaofei LvDepartment of Medical Imaging, Collaborative Innovation Centre for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Centre, Guangzhou 510060, PR China.
Meiqi NiuCenter for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, PR China.
Lizhi LiuDepartment of Medical Imaging, Collaborative Innovation Centre for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Centre, Guangzhou 510060, PR China.
Jun ChenCenter for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, PR China.
Fei XieDepartment of Medical Imaging, Collaborative Innovation Centre for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Centre, Guangzhou 510060, PR China.
Miao ZhongCenter for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, PR China.
Shijun QiuDepartment of Medical Imaging, The First Affiliated Hospital of Guangzhou University of Chinese Traditional Medicine, Guangzhou 510405, PR China.
Li LiDepartment of Medical Imaging, Collaborative Innovation Centre for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Centre, Guangzhou 510060, PR China.
Ruiwang HuangCenter for the Study of Applied Psychology, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional MRI studies showed that radiation-induced brain necrosis in patients with nasopharyngeal carcinoma (NPC) in years after radiotherapy (RT) could involve brain gray matter (GM) and impair brain function. However, it is still unclear the radiation-induced brain morphological changes in NPC patients with normal-appearing GM in the early period after RT. In this study, we acquired high-resolution brain structural MRI data from three groups of patients, 22 before radiotherapy (pre-RT) NPC patients with newly diagnosed but not yet medically treated, 22 NPC patients in the early-delayed stage after radiotherapy (post-RT-ED), and 20 NPC patients in the late-delayed stage after radiotherapy (post-RT-LD), and then analyzed the radiation-induced cortical thickness alteration in NPC patients after RT. Using a vertex-wise surface-based morphometry (SBM) approach, we detected significantly decreased cortical thickness in the precentral gyrus (PreCG) in the post-RT-ED group compared to the pre-RT group. And the post-RT-LD group showed significantly increased cortical thickness in widespread brain regions, including the bilateral inferior parietal, left isthmus of the cingulate, left bank of the superior temporal sulcus and left lateral occipital regions, compared to the pre-RT group, and in the bilateral PreCG compared to the post-RT-ED group. Similar analysis with ROI-wise SBM method also found the consistent results. These results indicated that radiation-induced brain injury mainly occurred in the post-RT-LD group and the cortical thickness alterations after RT were dynamic in different periods. Our findings may reflect the pathogenesis of radiation-induced brain injury in NPC patients with normal-appearing GM and an early intervention is necessary for protecting GM during RT.

Indexed as

AdultCarcinomaCerebral CortexFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsRadiotherapyStatistics, NonparametricYoung Adult2D-CRT, conventional two-dimensional radiotherapyAJCC, American Joint Committee on CancerANOVA, analysis of varianceBrain injurybSTS, bank of the superior temporal sulcusCMBs, cerebral microbleedscMFC, caudal middle frontal cortexCortical thicknessCT, cortical thicknessDMN, default mode networkFDR, false discovery rateFWHM, full width at half maximumGLM, general linear modelGM, gray matterICC, isthmus of the cingulate cortexIMRT, intensity-modulated radiation therapyIPC, inferior parietal cortexKPS, Karnofsky performance status scaleLOC, lateral occipital cortexMTC, middle temporal cortexNPC, nasopharyngeal carcinomaPoCG, postcentral gyruspost-RT-ED, in the early-delayed stage after radiotherapypost-RT-LD, in the late-delayed stage after radiotherapyPreCG, precentral gyrusPreCUN, precuneuspre-RT, before radiotherapyRadiotherapyRA, relative alterationRT, radiotherapySBM, surface-based morphometrySTC, superior temporal cortexStructural MRISurface-based morphometryVBM, voxel-based morphometryWM, white matter

Identifiers

PMID28348952
PMCPMC5357686

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.