ArticleFrontiers in neuroscience2017
Postnatal Dendritic Growth and Spinogenesis of Layer-V Pyramidal Cells Differ between Visual, Inferotemporal, and Prefrontal Cortex of the Macaque Monkey.
Article in Frontiers in neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- The role of sensory experience in the maturation of prefrontal cortical circuits.Frontiers in neuroscience · 2026Review
- Postnatal Development of the Perirhinal and Parahippocampal Cortices: A Stereological Study in Macaque Monkeys.The Journal of comparative neurology · 2026Article
- Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress.eNeuro · 2025Article
- Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development.Nature communications · 2024Article
- An Ultraflexible Electrode Array for Large-Scale Chronic Recording in the Nonhuman Primate Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Whole human-brain mapping of single cortical neurons for profiling morphological diversity and stereotypy.Science advances · 2023Article
- Introduction: What Are Dendritic Spines?Advances in neurobiology · 2023Article
- Self-tuition as an essential design feature of the brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Development of prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Working memory representations in visual cortex mediate distraction effects.Nature communications · 2021Article
- Postnatal Development of Glutamate and GABA Transcript Expression in Monkey Visual, Parietal, and Prefrontal Cortices.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Persistent Activity During Working Memory From Front to Back.Frontiers in neural circuits · 2021Review
- Pyramidal Cells in Olfactory Cortex.Chemical senses · 2021Article
- The Subcortical-Allocortical- NeocorticalFrontiers in synaptic neuroscience · 2021Article
- Developmental Changes in Pyramidal Cell Morphology in Multiple Visual Cortical Areas Using Cluster Analysis.Frontiers in computational neuroscience · 2021Article
- Learning Invariant Object and Spatial View Representations in the Brain Using Slow Unsupervised Learning.Frontiers in computational neuroscience · 2021Review
- Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro.Antioxidants (Basel, Switzerland) · 2020Article
- Invariant Synapse Density and Neuronal Connectivity Scaling in Primate Neocortical Evolution.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Anatomy and Physiology of Macaque Visual Cortical Areas V1, V2, and V5/MT: Bases for Biologically Realistic Models.Cerebral cortex (New York, N.Y. : 1991) · 2020Review
- The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyramidal cells in the primate cerebral cortex, particularly those in layer III, exhibit regional variation in both the time course and magnitude of postnatal growth and pruning of dendrites and spines. Less is known about the development of pyramidal cell dendrites and spines in other cortical layers. Here we studied dendritic morphology of layer-V pyramidal cells in primary visual cortex (V1, sensory), cytoarchitectonic area TE in the inferotemporal cortex (sensory association), and granular prefrontal cortex (Walker's area 12, executive) of macaque monkeys at the ages of 2 days, 3 weeks, 3.5 months, and 4.5 years. We found that changes in the basal dendritic field area of pyramidal cells were different across the three areas. In V1, field size became smaller over time (largest at 2 days, half that size at 4.5 years), in TE it did not change, and in area 12 it became larger over time (smallest at 2 days, 1.5 times greater at 4.5 years). In V1 and TE, the total number of branch points in the basal dendritic trees was similar between 2 days and 4.5 years, while in area 12 the number was greater in the adult monkeys than in the younger ones. Spine density peaked at 3 weeks and declined in all areas by adulthood, with V1 exhibiting a faster decline than area TE or area 12. Estimates of the total number of spines in the dendritic trees revealed that following the onset of visual experience, pyramidal cells in V1 lose more spines than they grow, whereas those in TE and area 12 grow more spines than they lose during the same period. These data provide further evidence that the process of synaptic refinement in cortical pyramidal cells differs not only according to time, but also location within the cortex. Furthermore, given the previous finding that layer-III pyramidal cells in all these areas exhibit the highest density and total number of spines at 3.5 months, the current results indicate that pyramidal cells in layers III and V develop spines at different rates.
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