Evidence map›Paper›PMID 28348500›Full record

ArticleJournal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America2017

Regression Models For Multivariate Count Data.

Yiwen Zhang, Hua Zhou, Jin Zhou, Wei Sun

Abstract read
In one paragraph

Article in Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Statistical Picking of Multivariate Waveforms.Sensors (Basel, Switzerland) · 2022
    Article
  7. Article
  8. Article
  9. Multivariate Analysis and Modelling of multiple Brain endOphenotypes: Let's MAMBO!Computational and structural biotechnology journal · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. svt: Singular Value Thresholding in MATLAB.Journal of statistical software · 2017
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yiwen ZhangDepartment of Statistics, North Carolina State University, Raleigh, NC 27695-8203.
Hua ZhouDepartment of Biostatistics, University of California, Los Angeles, Los Angeles, CA 90095-1772.
Jin ZhouDivision of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ 85721-0066.
Wei SunProgram in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
STATISTICAL METHODS FOR GENE MAPPINGR01GM053275 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGE, KENNETH L · 1995 to 2019
$9.3M
Genomics, GPUs, and Next Generation Computational StatisticsR01HG006139 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SOBEL, ERIC · 2011 to 2023
$5.1M
Statistical Methods for RNA-seq Data AnalysisR01GM105785 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Wei Sun · 2014 to 2026
$4.6M
Develop T2D Patient-Centered Treatment Suggestion Rule using EMR dataK01DK106116 · NIDDK · UNIVERSITY OF ARIZONA · PI ZHOU, JIN · 2016 to 2019
$524k
NCI NIH HHS P30 CA015704NHGRI NIH HHS R01 HG006139NIDDK NIH HHS K01 DK106116NIGMS NIH HHS R01 GM053275NIGMS NIH HHS R01 GM105785
6 · The paper itself

Abstract

Data with multivariate count responses frequently occur in modern applications. The commonly used multinomial-logit model is limiting due to its restrictive mean-variance structure. For instance, analyzing count data from the recent RNA-seq technology by the multinomial-logit model leads to serious errors in hypothesis testing. The ubiquity of over-dispersion and complicated correlation structures among multivariate counts calls for more flexible regression models. In this article, we study some generalized linear models that incorporate various correlation structures among the counts. Current literature lacks a treatment of these models, partly due to the fact that they do not belong to the natural exponential family. We study the estimation, testing, and variable selection for these models in a unifying framework. The regression models are compared on both synthetic and real RNA-seq data.

Indexed as

analysis of deviancecategorical data analysisDirichlet-multinomialgeneralized Dirichlet-multinomialiteratively reweighted Poisson regression (IRPR)negative multinomialreduced rank GLMregularization

Identifiers

PMID28348500
PMCPMC5365157

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.