Evidence map›Paper›PMID 28348486›Full record

ArticleWorld journal of gastroenterology2017

Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8

Hai-Mei Zhao, Fei Han, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Han-Lin Xu and 1 more

Open access · hybridAbstract read
In one paragraph

Article in World journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hai-Mei ZhaoHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Fei HanHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Rong XuHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Xiao-Ying HuangHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Shao-Min ChengHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Min-Fang HuangHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Hai-Yang YueHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Xin WangHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Yong ZouHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Han-Lin XuHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Duan-Yong LiuHai-Mei Zhao, Shao-Min Cheng, School of Basic Medical Sciences, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China.
Jiangxi University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8

methodsWe evaluated the suppressive effect of Cur on CD8

resultsThe disease activity index, colon weight, weight index of colon and histological score of experimental colitis were obviously decreased after Cur treatment, while the body weight and colon length recovered. After treatment with Cur, CD8

conclusionCur can effectively treat experimental colitis, which is realized by inhibiting CD8

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCD11c AntigenCD8-Positive T-LymphocytesColitisColonCurcuminDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFlow CytometryInterferon-gammaInterleukin-10Intestinal MucosaMaleMiceMice, Inbred C57BLAnti-Inflammatory Agents, Non-SteroidalCD11c AntigenCurcuminIFNG protein, mouseIL10 protein, mouseInterferon-gammaInterleukin-10Tgfb1 protein, mouseTransforming Growth Factor beta1Trinitrobenzenesulfonic AcidCD11cCD8CurcuminExperimental colitisTherapeutic effect

Identifiers

PMID28348486
PMCPMC5352921
OpenAlexW2595963787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.