ArticleMolecular psychiatry2018
Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study.
Article in Molecular psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Association of caesarean delivery with offspring health outcomes in full-cohort versus sibling-comparison studies: a comparative meta-analysis and simulation study.BMC medicine · 2023Pooled it
- The genetic epidemiology of obsessive-compulsive disorder: a systematic review and meta-analysis.Translational psychiatry · 2023Pooled it
- The correlation between prenatal maternal active smoking and neurodevelopmental disorders in children: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Investigation of gene-environment interactions in relation to tic severity.Journal of neural transmission (Vienna, Austria : 1996) · 2021Pooled it
- Early environmental risk factors for neurodevelopmental disorders - a systematic review of twin and sibling studies.Development and psychopathology · 2021Pooled it
- Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review.Translational psychiatry · 2021Pooled it
- Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Association of cumulative early medical events and neurodevelopmental conditions through a common latent factor-A population-based twin study.JCPP advances · 2026Article
- The Prevalence of Tic Disorders in Poland: Regional and Sex Differences.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Pregnancy Outcomes in Women Diagnosed With Attention-Deficit/Hyperactivity Disorder: A Population-Based Register Study.Acta psychiatrica Scandinavica · 2026Article
- Early developmental milestones associated with tics and psychopathological comorbidity: An EMTICS study.European child & adolescent psychiatry · 2025Observational
- [Update on tic disorders and Tourette syndrome].Der Nervenarzt · 2025Review
- Harnessing the microbiota-gut-brain axis to prevent and treat pediatric neurodevelopmental disorders: translational insights and strategies.Journal of translational medicine · 2025Review
- Environmental moderators of tic severity and quality of life in children with tic disorders.European journal of pediatrics · 2025Article
- Prenatal and early childhood infections requiring hospitalization and risk of neurodevelopmental disorders in offspring: a population-based birth cohort study in Taiwan.Molecular psychiatry · 2025Article
- Prolonged screen time is associated with increased severity of tic symptoms in children with tic disorders.Italian journal of pediatrics · 2025Article
- MicroRNA-429 Inhibits Microglial Inflammation by TargetingMediators of inflammation · 2025Article
- Associations of paternal age with offspring under-five mortality and perinatal outcomes: a cohort study using claims data in Taiwan.BMJ public health · 2024Article
- Prenatal Tobacco Exposure and Behavioral Disorders in Children and Adolescents: Systematic Review and Meta-Analysis.Pediatric reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse perinatal events may increase the risk of Tourette's and chronic tic disorders (TD/CTD), but previous studies have been unable to control for unmeasured environmental and genetic confounding. We aimed to prospectively investigate potential perinatal risk factors for TD/CTD, taking unmeasured factors shared between full siblings into account. A population-based birth cohort, consisting of all singletons born in Sweden in 1973-2003, was followed until December 2013. A total of 3 026 861 individuals were identified, 5597 of which had a registered TD/CTD diagnosis. We then studied differentially exposed full siblings from 947 942 families; of these, 3563 families included siblings that were discordant for TD/CTD. Perinatal data were collected from the Medical Birth Register and TD/CTD diagnoses were collected from the National Patient Register, using a previously validated algorithm. In the fully adjusted models, impaired fetal growth, preterm birth, breech presentation and cesarean section were associated with a higher risk of TD/CTD, largely independent from shared family confounders and measured covariates. Maternal smoking during pregnancy was associated with risk of TD/CTD in a dose-response manner but the association was no longer statistically significant in the sibling comparison models or after the exclusion of comorbid attention-deficit/hyperactivity disorder. A dose-response relationship between the number of adverse perinatal events and increased risk for TD/CTD was also observed, with hazard ratios ranging from 1.41 (95% confidence interval (CI): 1.33-1.50) for one event to 2.42 (95% CI: 1.65-3.53) for five or more events. These results pave the way for future gene by environment interaction and epigenetic studies in TD/CTD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.