ArticleMolecular psychiatry2017
Delta-frequency stimulation of cerebellar projections can compensate for schizophrenia-related medial frontal dysfunction.
Article in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Cerebellar stimulation in schizophrenia: A systematic review of the evidence and an overview of the methods.Frontiers in psychiatry · 2022Pooled it
- Cerebral Cortical Activity Following Non-invasive Cerebellar Stimulation-a Systematic Review of Combined TMS and EEG Studies.Cerebellum (London, England) · 2020Pooled it
- Cerebellar Theta Frequency Transcranial Pulsed Stimulation Increases Frontal Theta Oscillations in Patients with Schizophrenia.Cerebellum (London, England) · 2019Trial
- EEG-ECeG Coherence Mapping of Human Cerebro-cerebellar Projections: An Exploratory Study.Cerebellum (London, England) · 2026Article
- IMPAIRED BRIDGING OF TEMPORAL DISCONTINUITIES IN OLDER ADULT HIV-1 TG RATS.bioRxiv : the preprint server for biology · 2026Article
- Communication between the medial frontal cortex and mediodorsal thalamus is required for timing performance in rats.Neurobiology of learning and memory · 2026Article
- Stimulus Contingency and Task Context Encoding within the Anterior Cingulate-Amygdala-Cerebellum Associative Learning Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Amphetamine increases timing variability by degrading prefrontal temporal encoding.Neuropharmacology · 2025Article
- Article
- Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact.Cerebellum (London, England) · 2024Article
- New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment.Frontiers in cellular neuroscience · 2024Review
- Efficacy of the combination of water aerobics and metacognitive training on psychological and physical health variables and their relationship with SP1 and SP4 biomarkers in people with psychosis: a study protocol.Frontiers in psychology · 2024Article
- Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status.International journal of bipolar disorders · 2023Article
- Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status.Research square · 2023Article
- The cerebellum regulates fear extinction through thalamo-prefrontal cortex interactions in male mice.Nature communications · 2023Article
- Cerebellar contributions across behavioural timescales: a review from the perspective of cerebro-cerebellar interactions.Frontiers in systems neuroscience · 2023Review
- Cerebellar transcranial magnetic stimulation in psychotic disorders: intermittent, continuous, and sham theta-burst stimulation on time perception and symptom severity.Frontiers in psychiatry · 2023Article
- Thalamic Connectivity System Across Psychiatric Disorders: Current Status and Clinical Implications.Biological psychiatry global open science · 2022Review
- Functional Convergence of Motor and Social Processes in Lobule IV/V of the Mouse Cerebellum.Cerebellum (London, England) · 2021Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Schizophrenia involves abnormalities in the medial frontal cortex that lead to cognitive deficits. Here we investigate a novel strategy to normalize medial frontal brain activity by stimulating cerebellar projections. We used an interval timing task to study elementary cognitive processing that requires both frontal and cerebellar networks that are disrupted in patients with schizophrenia. We report three novel findings. First, patients with schizophrenia had dysfunctional delta rhythms between 1-4 Hz in the medial frontal cortex. We explored cerebellar-frontal interactions in animal models and found that both frontal and cerebellar neurons were modulated during interval timing and had delta-frequency interactions. Finally, delta-frequency optogenetic stimulation of thalamic synaptic terminals of lateral cerebellar projection neurons rescued timing performance as well as medial frontal activity in a rodent model of schizophrenia-related frontal dysfunction. These data provide insight into how the cerebellum influences medial frontal networks and the role of the cerebellum in cognitive processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.