ArticleNanomaterials (Basel, Switzerland)2014
Magnetite Nanoparticles Induce Genotoxicity in the Lungs of Mice via Inflammatory Response.
Article in Nanomaterials (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Genotoxicity assessment of mesoporous silica and graphene oxide in GDL1 cells.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025Article
- Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells.RSC advances · 2020Article
- Moringa seed extract alleviates titanium oxide nanoparticles (TiO2-NPs)-induced cerebral oxidative damage, and increases cerebral mitochondrial viability.Environmental science and pollution research international · 2020Article
- Iron Oxide Nanoparticle-Induced Neoplastic-Like Cell TransformationChemical research in toxicology · 2019Article
- In vitro detection of in vitro secondary mechanisms of genotoxicity induced by engineered nanomaterials.Particle and fibre toxicology · 2019Article
- Zinc Oxide Nanoparticles Induced Oxidative DNA Damage, Inflammation and Apoptosis in Rat's Brain after Oral Exposure.Toxics · 2018Article
- Establishment of an in vivo simulating co-culture assay platform for genotoxicity of multi-walled carbon nanotubes.Cancer science · 2018Article
- Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk.Nanomaterials (Basel, Switzerland) · 2017Review
- Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice.Particle and fibre toxicology · 2017Article
- Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells.International journal of molecular sciences · 2015Review
- Comprehensive DNA adduct analysis reveals pulmonary inflammatory response contributes to genotoxic action of magnetite nanoparticles.International journal of molecular sciences · 2015Article
- Challenges and Advances in Nanotoxicology.Nanomaterials (Basel, Switzerland) · 2014Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanomaterials are useful for their characteristic properties and are commonly used in various fields. Nanosized-magnetite (MGT) is widely utilized in medicinal and industrial fields, whereas their toxicological properties are not well documented. A safety assessment is thus urgently required for MGT, and genotoxicity is one of the most serious concerns. In the present study, we examined genotoxic effects of MGT using mice and revealed that DNA damage analyzed by a comet assay in the lungs of imprinting control region (ICR) mice intratracheally instilled with a single dose of 0.05 or 0.2 mg/animal of MGT was approximately two- to three-fold higher than that of vehicle-control animals. Furthermore, in
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