Evidence map›Paper›PMID 28348269›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Bonobos Maintain Immune System Diversity with Three Functional Types of MHC-B.

Emily E Wroblewski, Lisbeth A Guethlein, Paul J Norman, Yingying Li, Christiana M Shaw, Alex S Han, Jean-Bosco N Ndjango, Steve Ahuka-Mundeke, Alexander V Georgiev, Martine Peeters and 2 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

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  7. The HLA A03 Supertype and SeveralJournal of virology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Emily E WroblewskiDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; eewro1@stanford.edu peropa@stanford.edu.ORCID http://orcid.org/0000-0003-3032-6514
Lisbeth A GuethleinDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID http://orcid.org/0000-0002-1301-8301
Paul J NormanDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID http://orcid.org/0000-0001-8370-7703
Yingying LiDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Christiana M ShawDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Alex S HanDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305.ORCID http://orcid.org/0000-0002-8115-4217
Jean-Bosco N NdjangoDepartment of Ecology and Management of Plant and Animal Resources, Faculty of Sciences, University of Kisangani, 2012 Kisangani, Democratic Republic of the Congo.
Steve Ahuka-MundekeInstitut National de Recherche Biomédicales, 1197 Kinshasa, Democratic Republic of the Congo.
Alexander V GeorgievDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138.ORCID http://orcid.org/0000-0001-5622-3826
Martine PeetersInstitut de Recherche pour le Développement, Université de Montpellier, 34394 Montpellier, France; and.
Beatrice H HahnDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID http://orcid.org/0000-0002-9400-9887
Peter ParhamDepartment of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; eewro1@stanford.edu peropa@stanford.edu.
Stanford University · USUniversity of Pennsylvania · USUniversité de Montpellier · FRHarvard University · USUniversité de Kisangani · CD

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
GENETICS TRAINING PROGRAM FOR PHD CANDIDATEST32GM007790 · NIGMS · STANFORD UNIVERSITY · PI BRUNET, ANNE, KINGSLEY, DAVID M · 1985 to 2020
$12.8M
Natural SIV Reservoirs and Human Zoonotic RiskR37AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2008 to 2017
$5.7M
Great Ape Reservoirs of Human MalariaR01AI091595 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2011 to 2019
$5.3M
THE NATURE AND FUNCTION OF HLA-A,B,C POLYMORPHISMR01AI024258 · NIAID · STANFORD UNIVERSITY · PI PARHAM, PETER R · 1986 to 2020
$5.3M
Origins of Diversity at Human Classical MHC Class I GenesR01AI031168 · NIAID · STANFORD UNIVERSITY · PI PARHAM, PETER R · 1991 to 2013
$3.8M
Studies of the precursor of the human AIDS virus in its natural chimpanzee hostR01AI120810 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2016 to 2020
$3.4M
NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI024258NIAID NIH HHS R01 AI031168NIAID NIH HHS R01 AI091595NIAID NIH HHS R01 AI120810NIAID NIH HHS R37 AI050529NIGMS NIH HHS T32 GM007790NIH HHS P51 OD011132
6 · The paper itself

Abstract

Fast-evolving MHC class I polymorphism serves to diversify NK cell and CD8 T cell responses in individuals, families, and populations. Because only chimpanzee and bonobo have strict orthologs of all

Indexed as

Immune SystemPan paniscusAnimalsBiological EvolutionGene FrequencyGenotypeGorilla gorillaHistocompatibility Antigens Class IHLA-B AntigensHumansImmunodominant EpitopesKiller Cells, NaturalPan troglodytesPhylogenyPolymorphism, GeneticHistocompatibility Antigens Class IHLA-B AntigensImmunodominant Epitopes

Identifiers

PMID28348269
PMCPMC5469624
OpenAlexW2611153640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.