ArticleBMJ case reports2017
Rare progression of cholangiocarcinoma: distal femoral metastasis.
Article in BMJ case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Distal cholangiocarcinoma with rare progression to distal femoral metastasis: a case report and literature review.Frontiers in medicine · 2026Article
- Pathological Clavicle Fracture: Initial Presentation of Intrahepatic Cholangiocarcinoma.Cureus · 2020Article
- Bone metastasis from cholangiocarcinoma mimicking osteosarcoma: A case report and review literature.Molecular and clinical oncology · 2018Article
- Paraparesis and Disseminated Osteolytic Lesions Revealing Cholangiocarcinoma: A Case Report.Journal of medicine and lifeArticle
- Diffuse bone metastasis from cholangiocarcinoma involving the sternum: A case report and review of literature.International journal of critical illness and injury scienceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cholangiocarcinoma (CCA) is a rare cancer of the bile duct epithelial cells, with metastases to long bones rarely reported. We present the case of a woman aged 61 years, diagnosed with CCA 6 years previously. She presented with right thigh discomfort, rapidly progressing to immobility with severe pain. Radiological investigations revealed a lytic lesion in her right distal femur, most likely a metastatic deposit, at high risk of pathological fracture. This was managed with an en bloc resection and implantation of a distal femoral replacement. Pathology specimens from theatre confirmed metastatic CCA. Despite sustaining a subsequent fractured neck of femur on the operative side, she recovered well from surgery, with minimal pain and improved mobility on discharge. She restarted palliative chemotherapy. This case illustrates the option of definitive major surgery for the management of metastatic bone disease. As in this case, this can lead to improved symptom control and quality of remaining life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.