Evidence map›Paper›PMID 28348246›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Mechanism of transcription initiation and promoter escape by

Kate L Henderson, Lindsey C Felth, Cristen M Molzahn, Irina Shkel, Si Wang, Munish Chhabra, Emily F Ruff, Lauren Bieter, Joseph E Kraft, M Thomas Record

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
  2. Article
  3. DNA topological regulation in RNA polymerase II transcription.Cellular & molecular biology letters · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. RNAP Promoter Search and Transcription Kinetics in LiveThe journal of physical chemistry. B · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kate L HendersonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Lindsey C FelthDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Cristen M MolzahnDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Irina ShkelDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Si WangDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Munish ChhabraProgram in Biophysics, University of Wisconsin-Madison, Madison, WI 53706.
Emily F RuffDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Lauren BieterDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Joseph E KraftDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
M Thomas RecordDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706; mtrecord@wisc.edu.
University of Wisconsin–Madison · US

Funding

Mechanisms of RNA Polymerase-Promoter and lac Repressor-Operator InteractionsR35GM118100 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RECORD, M. THOMAS · 2016 to 2020
$2.6M
Roles of RNA Polymerase Downstream Mobile Elements in Transcription InitiatiR01GM103061 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RECORD, M. THOMAS · 2012 to 2015
$1.1M
Promoter and RNA Polymerase Determinants in Transcription InitiationF32GM122303 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HENDERSON, KATE LYNNE · 2017 to 2018
$116k
NIGMS NIH HHS F32 GM122303NIGMS NIH HHS R01 GM103061NIGMS NIH HHS R35 GM118100
6 · The paper itself

Abstract

To investigate roles of the discriminator and open complex (OC) lifetime in transcription initiation by

Indexed as

Promoter Regions, GeneticTranscription, GeneticDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coliModels, MolecularNucleic Acid ConformationProtein BindingTranscription Initiation SiteDNA, BacterialDNA-Directed RNA Polymerasesabortive RNAhybrid lengthopen complex lifetimeRNA polymerasetranscription initiation

Identifiers

PMID28348246
PMCPMC5393250
OpenAlexW2597915083

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.