Evidence map›Paper›PMID 28348233›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease.

Tamara L Lenis, Shanta Sarfare, Zhichun Jiang, Marcia B Lloyd, Dean Bok, Roxana A Radu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Trial
  2. Review
  3. Dysregulated DNA Methylation inInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Global Treatment Approaches Part 1: Neuroprotection and Stem Cell Therapy.Advances in experimental medicine and biology · 2025
    Review
  8. Review
  9. Review
  10. Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tamara L LenisStein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Shanta SarfareStein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Zhichun JiangStein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Marcia B LloydStein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Dean BokStein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Roxana A RaduStein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; radu@jsei.ucla.edu.ORCID 0000-0002-5064-6403

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Gregory Darin Field, DAVID S WILLIAMS · 1985 to 2026
$16.8M
The Role of Complement in Recessive Stargardt DiseaseR01EY025002 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RADU, ROXANA A · 2015 to 2019
$1.9M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY025002
6 · The paper itself

Abstract

Recessive Stargardt macular degeneration (STGD1) is caused by mutations in the gene for the ABCA4 transporter in photoreceptor outer segments. STGD1 patients and

Indexed as

AnimalsATP-Binding Cassette TransportersAutophagyComplement C3DependovirusDisease Models, AnimalGene Expression RegulationInjections, IntraocularLipofuscinMacular DegenerationMice, Inbred BALB CMice, Mutant StrainsOxidative StressPhotoreceptor Cells, VertebrateReceptors, ComplementReceptors, Complement 3bAbca4 protein, mouseATP-Binding Cassette TransportersComplement C3Cr1l protein, mouseLipofuscinReceptors, ComplementReceptors, Complement 3bRetinoidsbisretinoidscomplement systemgene therapyrecessive Stargardt macular degenerationretinal pigment epithelium

Identifiers

PMID28348233
PMCPMC5393232

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.