Evidence map›Paper›PMID 28348228›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate.

Shinobu Hirai, Kohji Hotta, Yoshihiro Kubo, Atsuo Nishino, Shigeo Okabe, Yasushi Okamura, Haruo Okado

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Transitions of motor neuron activities duringFrontiers in cell and developmental biology · 2023
    Article
  4. Article
  5. Article
  6. Dysregulated CaFrontiers in synaptic neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Shinobu HiraiDepartment of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-0057, Japan.
Kohji HottaDepartment of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kohoku, Yokohama, 223-8522, Japan.
Yoshihiro KuboDivision of Biophysics and Neurobiology, Department of Molecular Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan.
Atsuo NishinoDepartment of Biology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki, Aomori 036-8561, Japan.
Shigeo OkabeDepartment of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.
Yasushi OkamuraDepartment of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan.
Haruo OkadoDepartment of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-0057, Japan; okado-hr@igakuken.or.jp.
Tokyo Metropolitan Institute of Medical Science · JPHirosaki University · JPKeio University · JPNational Institute for Physiological Sciences · JPOsaka University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AMPA-type glutamate receptors (GluAs) mediate fast excitatory transmission in the vertebrate central nervous system (CNS), and their function has been extensively studied in the mature mammalian brain. However, GluA expression begins very early in developing embryos, suggesting that they may also have unidentified developmental roles. Here, we identify developmental roles for GluAs in the ascidian

Indexed as

Amino Acid SubstitutionAnimalsCalciumCiona intestinalisFemaleGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGreen Fluorescent ProteinsLarvaMaleMorphogenesisOocytesReceptors, GlutamateSense OrgansXenopusCalciumGreen Fluorescent ProteinsReceptors, GlutamateAMPA-type glutamate receptorascidiandevelopmentmorphogeneis

Identifiers

PMID28348228
PMCPMC5393200
OpenAlexW2602723995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.