Evidence map›Paper›PMID 28348223›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Quantification of circulating

Chang Liu, Zhen Zhao, Jia Fan, Christopher J Lyon, Hung-Jen Wu, Dobrin Nedelkov, Adrian M Zelazny, Kenneth N Olivier, Lisa H Cazares, Steven M Holland and 2 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03271567 (Detection of Circulating Mycobacterium Tuberculosis Antigen Peptides for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients), which is not on this map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03271567 completednot on this map

Detection of Circulating Mycobacterium Tuberculosis Antigen Peptides for the Diagnosis of Active Pulmonary and Extrapulmonary Tuberculosis in Hospitalized Patients

TypeobservationalSponsorChinese University of Hong KongRan2017 to 2019Enrolled100ConditionsActive Tuberculosis, Tuberculosis, Extrapulmonary, Tuberculosis, PulmonaryArmsNanodisk-MS assay
3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Tuberculosis treatment and cytotoxic immune signatures: a longitudinal study.Journal of clinical tuberculosis and other mycobacterial diseases · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Antigen specificity shapes antibody functions in tuberculosis.bioRxiv : the preprint server for biology · 2024
    Article
  12. Review
  13. Review
  14. Article
  15. Plasma/Serum Proteomics based on Mass Spectrometry.Protein and peptide letters · 2024
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Chang LiuDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030.
Zhen ZhaoDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Jia FanDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030.
Christopher J LyonDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030.
Hung-Jen WuDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030.
Dobrin NedelkovMolecular Biomarkers Laboratory, The Biodesign Institute, Arizona State University, Tempe, AZ 85287.
Adrian M ZelaznyDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892.
Kenneth N OlivierCardiovascular and Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.
Lisa H CazaresMolecular and Translational Sciences, US Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702.
Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Edward A GravissDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX 77030.
Ye HuDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030; tyhu@asu.edu.
Houston Methodist · USArizona State University · USNational Institutes of Health Clinical Center · USNational Heart Lung and Blood Institute · USNational Institute of Allergy and Infectious Diseases · USUnited States Army Medical Research Institute of Infectious Diseases · US

Funding

Bronchiectasis and chronic airway infectionZIAHL006200 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FENNELLY, KEVIN · 2015 to 2025
$25.1M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Direct quantitation of the circulating Mtb-peptidome for pediatric TB managementR01HD090927 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI Christopher J Lyon, Charles DeBeaux Mitchell · 2017 to 2026
$4.5M
Quantification of Circulating Antigens for Pediatric TB Diagnosis andTreatment MonitoringR01AI122932 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI HU, TONY Y. · 2016 to 2019
$1.8M
Real-time Detection of Active TB in HIV Exposed Children on CustomizedNanotrapR01AI113725 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI LABAER, JOSHUA · 2015 to 2018
$1.6M
Multiplexed quantification of circulating peptidomic signatures for EBOLA early diagnosisR21AI126361 · NIAID · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LABAER, JOSHUA · 2017 to 2018
$373k
Identification of Clinically Important Microbes by Genomic and Proteomic MethodsZIACL080012 · CLC · CLINICAL CENTER · PI ZELAZNY, ADRIAN MARCELO · 2009 to 2025
$0k
NCATS NIH HHS UL1 TR000371NIAID NIH HHS R01 AI113725NIAID NIH HHS R01 AI122932NIAID NIH HHS R21 AI126361NICHD NIH HHS R01 HD090927
6 · The paper itself

Abstract

Tuberculosis (TB) is a major global health threat, resulting in an urgent unmet need for a rapid, non-sputum-based quantitative test to detect active

Indexed as

AdultAgedAged, 80 and overAntigens, BacterialBacterial ProteinsCase-Control StudiesFemaleHIV SeropositivityHumansMaleMiddle AgedMycobacterium tuberculosisNanoparticlesPeptidesSensitivity and SpecificitySpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAntigens, BacterialBacterial ProteinsCFP-10 protein, Mycobacterium tuberculosisESAT-6 protein, Mycobacterium tuberculosisMycobacterium tuberculosis antigensPeptidesblood testnanodiskrapid diagnosistreatment monitoringtuberculosis

Identifiers

PMID28348223
PMCPMC5393254
OpenAlexW2603710736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.