Evidence map›Paper›PMID 28348215›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

PLP and GABA trigger GabR-mediated transcription regulation in

Rui Wu, Ruslan Sanishvili, Boris R Belitsky, Jose I Juncosa, Hoang V Le, Helaina J S Lehrer, Michael Farley, Richard B Silverman, Gregory A Petsko, Dagmar Ringe and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  5. Genetic Foundations of Direct Ammonia Oxidation (Dirammox) to NApplied and environmental microbiology · 2022
    Article
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  11. Article
  12. Determination of Ligand Profiles forInternational journal of molecular sciences · 2019
    Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Rui WuDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660.
Ruslan SanishviliGM/CA@APS, The X-Ray Science Division, the Advanced Photon Source, Argonne National Laboratory, Lemont, IL 60439.
Boris R BelitskyDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Jose I JuncosaDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL 60208-3113.
Hoang V LeDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL 60208-3113.
Helaina J S LehrerDepartment of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Michael FarleyDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660.
Richard B SilvermanDepartment of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Northwestern University, Evanston, IL 60208-3113.
Gregory A PetskoDepartment of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454; dliu@luc.edu gpetsko@med.cornell.edu.
Dagmar RingeDepartment of Biochemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454.
Dali LiuDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660; dliu@luc.edu gpetsko@med.cornell.edu.
Loyola University Chicago · USNorthwestern University · USBrandeis University · USArgonne National Laboratory · USMIND Research Institute · USTufts University · US

Funding

New Inactivators of GABA Aminotransferase for Addiction and EpilepsyR01DA030604 · NIDA · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2011 to 2020
$4.0M
Molecular Mechanism and Ligand Design of a PLP/GABA-dependent Bacterial Transcription Regulator GabRR15GM113229 · NIGMS · LOYOLA UNIVERSITY OF CHICAGO · PI LIU, DALI · 2015 to 2015
$332k
NIDA NIH HHS R01 DA030604NIGMS NIH HHS R15 GM113229
6 · The paper itself

Abstract

The

Indexed as

Gene Expression Regulation, BacterialBacillus subtilisBacterial ProteinsBinding SitesCrystallography, X-Raygamma-Aminobutyric AcidMagnetic Resonance SpectroscopyOperonPentanoic AcidsPromoter Regions, GeneticProtein DomainsPyridoxal PhosphateSchiff BasesTranscription, Genetic4-amino-5-fluoropentanoic acidBacterial Proteinsgamma-Aminobutyric AcidPentanoic AcidsPyridoxal PhosphateSchiff Basesexternal aldimineGabRMocRPLPtranscription activation

Identifiers

PMID28348215
PMCPMC5393194
OpenAlexW2599305930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.