ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Regulation of Synaptic Plasticity and Adaptive Convergence Under Rhythmic Stimulation of an In Vitro Hippocampal Neuronal Network of Cultured Cells.Biosensors · 2026Article
- BK channels mediate a presynaptic form of mGluR-LTD in the neonatal hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Challenges in the Therapeutic Targeting of KCa Channels: From Basic Physiology to Clinical Applications.International journal of molecular sciences · 2024Review
- A single base pair substitution in zebrafish distinguishes between innate and acute startle behavior regulation.PloS one · 2024Article
- Endogenous noise of neocortical neurons correlates with atypical sensory response variability in the Fmr1Nature communications · 2023Article
- Developmental changes in electrophysiological properties of auditory cortical neurons in theJournal of neurophysiology · 2023Article
- CaInternational journal of molecular sciences · 2023Review
- The Role of AMPARs Composition and Trafficking in Synaptic Plasticity and Diseases.Cellular and molecular neurobiology · 2022Review
- Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Brain-wide visual habituation networks in wild type and fmr1 zebrafish.Nature communications · 2022Article
- Small molecule modulation of the large-conductance calcium-activated potassium channel suppresses salicylate-induced tinnitus in mice.Frontiers in neuroscience · 2022Article
- A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes.Nature communications · 2021Article
- The amygdala modulates prepulse inhibition of the auditory startle reflex through excitatory inputs to the caudal pontine reticular nucleus.BMC biology · 2021Article
- GABAFrontiers in integrative neuroscience · 2021Article
- Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response.Brain research · 2019Article
- De novo loss-of-function KCNMA1 variants are associated with a new multiple malformation syndrome and a broad spectrum of developmental and neurological phenotypes.Human molecular genetics · 2019Article
- Altered Auditory Processing, Filtering, and Reactivity in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A BK channel-mediated feedback pathway links single-synapse activity with action potential sharpening in repetitive firing.Science advances · 2018Article
- Physiological Roles and Therapeutic Potential of CaFrontiers in molecular neuroscience · 2018Review
- Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Habituation is a basic form of implicit learning and represents a sensory filter that is disrupted in autism, schizophrenia, and several other mental disorders. Despite extensive research in the past decades on habituation of startle and other escape responses, the underlying neural mechanisms are still not fully understood. There is evidence from previous studies indicating that BK channels might play a critical role in habituation. We here used a wide array of approaches to test this hypothesis. We show that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, using patch-clamp recordings and voltage-sensitive dye imaging in slices. Furthermore, positive modulation of BK channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.