Evidence map›Paper›PMID 28348061›Full record

ArticleGenetics2017

Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in

Stephen M Blazie, Heather C Geissel, Henry Wilky, Rajan Joshi, Jason Newbern, Marco Mangone

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 81 citations in OpenAlex.

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  18. Unconventional Myosins fromBiomolecules · 2022
    Review
  19. Article
  20. Hand Dissection of Caenorhabditis elegans Intestines.Journal of visualized experiments : JoVE · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephen M BlazieMolecular and Cellular Biology Graduate Program, Arizona State University, Tempe, Arizona 85281.ORCID 0000-0001-6701-6275
Heather C GeisselMolecular and Cellular Biology Graduate Program, Arizona State University, Tempe, Arizona 85281.
Henry WilkyBarrett Honors College, Arizona State University, Tempe, Arizona 85281.
Rajan JoshiCollege of Letters and Sciences, Interdisciplinary Studies, Biological Sciences and Informatics, Arizona State University, Tempe, Arizona 85281.
Jason NewbernMolecular and Cellular Biology Graduate Program, Arizona State University, Tempe, Arizona 85281.
Marco MangoneMolecular and Cellular Biology Graduate Program, Arizona State University, Tempe, Arizona 85281 mangone@asu.edu.ORCID 0000-0001-7551-8793
Arizona State University · US

Funding

Genetics and Genomics of Alternative Polyadenylation and miRNA Regulation in C. e - Renewal - 1R01GM118796 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MANGONE, MARCO · 2016 to 2024
$2.8M
ERK/MAPK regulation of cortical inhibitory interneuronsR00NS076661 · NINDS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI NEWBERN, JASON MARSHALL · 2013 to 2015
$726k
Detection and validation of miRNA targets in breast cancerR21CA179144 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MANGONE, MARCO · 2014 to 2015
$354k
NCI NIH HHS R21 CA179144NIGMS NIH HHS R01 GM118796NINDS NIH HHS R00 NS076661
6 · The paper itself

Abstract

mRNA expression dynamics promote and maintain the identity of somatic tissues in living organisms; however, their impact in post-transcriptional gene regulation in these processes is not fully understood. Here, we applied the PAT-Seq approach to systematically isolate, sequence, and map tissue-specific mRNA from five highly studied

Indexed as

3' Untranslated RegionsAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease Models, AnimalGene Expression Regulation, DevelopmentalHumansMicroRNAsOrgan SpecificityPoly APolyadenylationReceptors, Cytoplasmic and Nuclear3' Untranslated RegionsCaenorhabditis elegans ProteinsMicroRNAsPoly ARACK-1 protein, C elegansReceptors, Cytoplasmic and Nuclearalternative polyadenylationC. elegansmiRNAtranscriptome

Identifiers

PMID28348061
PMCPMC5499184
OpenAlexW2603128153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.