Evidence map›Paper›PMID 28348051›Full record

ArticleInfection and immunity2017

Iron Efflux by PmtA Is Critical for Oxidative Stress Resistance and Contributes Significantly to Group A Streptococcus Virulence.

Arica R VanderWal, Nishanth Makthal, Azul Pinochet-Barros, John D Helmann, Randall J Olsen, Muthiah Kumaraswami

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Iron homeostasis inMicrobiology (Reading, England) · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Pathogens (Basel, Switzerland) · 2021
    Review
  14. Article
  15. Bacterial iron detoxification at the molecular level.The Journal of biological chemistry · 2020
    Review
  16. Review
  17. Article
  18. Article
  19. Iron Acquisition by Bacterial Pathogens: Beyond Tris-Catecholate Complexes.Chembiochem : a European journal of chemical biology · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Arica R VanderWalCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Nishanth MakthalCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Azul Pinochet-BarrosDepartment of Microbiology, Cornell University, Ithaca, New York, USA.
John D HelmannDepartment of Microbiology, Cornell University, Ithaca, New York, USA.ORCID http://orcid.org/0000-0002-3832-3249
Randall J OlsenCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA.
Muthiah KumaraswamiCenter for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas, USA mkumaraswami@houstonmethodist.org.
Houston Methodist · USCornell University · US

Funding

Bacillus subtilis Stress ResponsesR35GM122461 · NIGMS · CORNELL UNIVERSITY · PI John D Helmann · 2017 to 2026
$7.6M
Zinc Homeostasis in Bacillus subtilisR01GM059323 · NIGMS · CORNELL UNIVERSITY ITHACA · PI HELMANN, JOHN D · 2000 to 2017
$4.5M
Molecular mechanism of virulence regulation in Streptococcus pyogenesR01AI109096 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KUMARASWAMI, MUTHIAH · 2015 to 2019
$2.0M
NIAID NIH HHS R01 AI109096NIGMS NIH HHS R01 GM059323NIGMS NIH HHS R35 GM122461
6 · The paper itself

Abstract

Group A

Indexed as

Oxidative StressAnimalsBacterial ProteinsFemaleGene Expression Regulation, BacterialHydrogen PeroxideMethyltransferasesMiceRegulonRepressor ProteinsRNA, BacterialStreptococcal InfectionsStreptococcus pyogenesVirulenceBacterial ProteinsHydrogen PeroxideMethyltransferasesperoxide repressor proteinsPmtA protein, bacteriaRepressor ProteinsRNA, Bacterialbacterial pathogenesisgene regulationiron effluxmetal homeostasisoxidative stress

Identifiers

PMID28348051
PMCPMC5442632
OpenAlexW2600069741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.