Evidence map›Paper›PMID 28348009›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive Rat.

Sheon Mary, Heather Yvonne Small, Justyna Siwy, William Mullen, Ashok Giri, Christian Delles

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Uromodulin in mineral metabolism.Current opinion in nephrology and hypertension · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sheon MaryFrom the BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland (S.M., H.Y.S., W.M., C.D.); Department of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India (S.M., A.G.); and Mosaiques Diagnostics GmbH, Hannover, Germany (J.S.).
Heather Yvonne SmallFrom the BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland (S.M., H.Y.S., W.M., C.D.); Department of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India (S.M., A.G.); and Mosaiques Diagnostics GmbH, Hannover, Germany (J.S.).
Justyna SiwyFrom the BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland (S.M., H.Y.S., W.M., C.D.); Department of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India (S.M., A.G.); and Mosaiques Diagnostics GmbH, Hannover, Germany (J.S.).
William MullenFrom the BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland (S.M., H.Y.S., W.M., C.D.); Department of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India (S.M., A.G.); and Mosaiques Diagnostics GmbH, Hannover, Germany (J.S.).
Ashok GiriFrom the BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland (S.M., H.Y.S., W.M., C.D.); Department of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India (S.M., A.G.); and Mosaiques Diagnostics GmbH, Hannover, Germany (J.S.).
Christian DellesFrom the BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Scotland (S.M., H.Y.S., W.M., C.D.); Department of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune, India (S.M., A.G.); and Mosaiques Diagnostics GmbH, Hannover, Germany (J.S.). Christian.Delles@glasgow.ac.uk.
National Chemical Laboratory · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The kidney is centrally involved in blood pressure regulation and undergoes extensive changes during pregnancy. Hypertension during pregnancy may result in an altered urinary peptidome that could be used to indicate new targets of therapeutic or diagnostic interest. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of maternal chronic hypertension. Capillary electrophoresis-mass spectrometry was conducted to interrogate the urinary peptidome in SHRSP and the control Wistar-Kyoto strain at three time points: prepregnancy and gestational days 12 and 18. The comparison within and between the Wistar-Kyoto and SHRSP peptidome at all time points detected 123 differentially expressed peptides (fold change >1.5;

Indexed as

AnimalsAntihypertensive AgentsFemaleHypertension, Pregnancy-InducedKidneyNifedipinePolymerizationPregnancyRatsRats, Inbred SHRUromodulinAntihypertensive AgentsNifedipineUromodulinhypertensionkidneyNifedipinepregnancyuromodulin

Identifiers

PMID28348009
PMCPMC5389592
OpenAlexW2601299902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.