Evidence map›Paper›PMID 28348008›Full record

ArticleHypertension (Dallas, Tex. : 1979)2017

Impaired Hydrogen Sulfide-Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults.

Jody L Greaney, Jessica L Kutz, Sean W Shank, Sandeep Jandu, Lakshmi Santhanam, Lacy M Alexander

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 89 citations in OpenAlex.

  1. Unravelling the Therapeutic Potential of Cysteine for Cardiovascular Health.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Comparing cutaneous NO-dependent vasodilation between young males and females.medRxiv : the preprint server for health sciences · 2026
    Article
  4. Review
  5. Black gas, bright future: HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Altered Production and Cellular Levels of Hydrogen Sulfide (HPathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  11. The interplay of hydrogen sulfide and microRNAs in cardiovascular diseases: insights and future perspectives.Mammalian genome : official journal of the International Mammalian Genome Society · 2024
    Review
  12. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Utility of NO and HNitric oxide : biology and chemistry · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jody L GreaneyFrom the Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park (J.L.G., J.L.K., S.W.S., L.M.A.); Department of Exercise Science, Shenandoah University, Winchester, VA (J.L.K.); and Departments of Anesthesia and Critical Care Medicine and Bioengineering, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.).
Jessica L KutzFrom the Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park (J.L.G., J.L.K., S.W.S., L.M.A.); Department of Exercise Science, Shenandoah University, Winchester, VA (J.L.K.); and Departments of Anesthesia and Critical Care Medicine and Bioengineering, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.).
Sean W ShankFrom the Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park (J.L.G., J.L.K., S.W.S., L.M.A.); Department of Exercise Science, Shenandoah University, Winchester, VA (J.L.K.); and Departments of Anesthesia and Critical Care Medicine and Bioengineering, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.).
Sandeep JanduFrom the Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park (J.L.G., J.L.K., S.W.S., L.M.A.); Department of Exercise Science, Shenandoah University, Winchester, VA (J.L.K.); and Departments of Anesthesia and Critical Care Medicine and Bioengineering, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.).
Lakshmi SanthanamFrom the Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park (J.L.G., J.L.K., S.W.S., L.M.A.); Department of Exercise Science, Shenandoah University, Winchester, VA (J.L.K.); and Departments of Anesthesia and Critical Care Medicine and Bioengineering, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.).
Lacy M AlexanderFrom the Department of Kinesiology, Noll Laboratory, The Pennsylvania State University, University Park (J.L.G., J.L.K., S.W.S., L.M.A.); Department of Exercise Science, Shenandoah University, Winchester, VA (J.L.K.); and Departments of Anesthesia and Critical Care Medicine and Bioengineering, Johns Hopkins University School of Medicine, Baltimore, MD (S.J., L.S.). lma191@psu.edu.
Shenandoah University · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
Essential Hypertension & Human Skin Blood FlowR01HL093238 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI ALEXANDER, LACY M. · 2009 to 2018
$4.3M
Psychosocial Determinants and Biological Pathway to Healthy Aging (Pathways)T32AG049676 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LYNN M. MARTIRE · 2016 to 2026
$3.9M
NRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4M
NCATS NIH HHS TL1 TR002016NCATS NIH HHS UL1 TR002014NHLBI NIH HHS R01 HL093238NIA NIH HHS T32 AG049676
6 · The paper itself

Abstract

Reductions in hydrogen sulfide (H

Indexed as

AcetylcholineBlood PressureEndothelium, VascularFemaleHumansHydrogen SulfideHypertensionLaser-Doppler FlowmetryMaleMicrovesselsMiddle AgedSkinVasodilationAcetylcholineHydrogen Sulfide3-mercaptopyruvate sulfurtransferasecystathionine γ-lyaseendothelial dysfunctionendothelium-dependent dilationmicrodialysisnitric oxide

Identifiers

PMID28348008
PMCPMC5391285
OpenAlexW2601591567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.