Observational studyThe British journal of general practice : the journal of the Royal College of General Practitioners2017
Clinical features of bowel disease in patients aged <50 years in primary care: a large case-control study.
Observational study in The British journal of general practice : the journal of the Royal College of General Practitioners, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Development, validation and effectiveness of diagnostic prediction tools for colorectal cancer in primary care: a systematic review.BMC cancer · 2020Pooled it
- Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials.Nutrients · 2020Pooled it
- Gastrointestinal Tract Remodeling by Dietary Polysaccharides Mechanistic Insights in Colitis-A Review.Foods (Basel, Switzerland) · 2026Review
- Cancer risk in patients with recurrent or persistent symptoms: a systematic review.The Lancet regional health. Europe · 2026Review
- Knowledge, Symptom Awareness, and Referral Practices of Primary Care Providers in Early-Onset Colorectal Cancer.Population health management · 2026Article
- A Network-Based Association of IBD and Colorectal Cancer Using Proteomics Data.Proteomics. Clinical applications · 2026Article
- Evaluating the role of faecal calprotectin in older adults: a retrospective observational study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Observational
- The diagnostic accuracy of the faecal immunochemical test for the detection of early-onset colorectal cancer: an age-stratified analysis in South West England.British journal of cancer · 2025Article
- Anaemia, ethnicity, and cancer incidence: a retrospective cohort study in primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- No Time for Waste! Co-Producing Practice Guidelines and Research Recommendations to Promote Earlier Diagnosis of Colorectal Cancer in Community Pharmacies: A Qualitative Analysis.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Identification of Cohorts with Inflammatory Bowel Disease Amidst Fragmented Clinical Databases via Machine Learning.Digestive diseases and sciences · 2025Article
- A UK population-based case-control study of blood tests before cancer diagnosis in patients with non-specific abdominal symptoms.British journal of cancer · 2025Article
- Optimising triage of urgent referrals for suspected IBD: results from the Birmingham IBD inception study.Frontline gastroenterology · 2024Article
- Associations between prior healthcare use, time to diagnosis, and clinical outcomes in inflammatory bowel disease: a nationally representative population-based cohort study.BMJ open gastroenterology · 2024Article
- The performance of FIT-based and other risk prediction models for colorectal neoplasia in symptomatic patients: a systematic review.EClinicalMedicine · 2023Review
- Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease.Journal of clinical medicine · 2023Review
- Clinicopathological patterns and survival outcomes of colorectal cancer among young adults in Malaysia: an institutional cohort study.Singapore medical journal · 2021Article
- Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK: A cohort study.PLoS medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncidences of colorectal cancer (CRC) and inflammatory bowel disease (IBD) are increasing in those aged <50 years.
aimTo identify and quantify clinical features in primary care of CRC/IBD in those aged <50 years. This study considered the two conditions together and aimed to determine which younger patients, presenting in primary care with symptoms, would benefit from investigation for potentially serious colorectal disease. DESIGN AND
settingMatched case-control study using primary care records from the Clinical Practice Research Datalink, UK.
methodIncident cases (aged <50 years) of CRC (
resultsTen features were independently associated with CRC/IBD (all
conclusionThis study quantified the risk of serious bowel disease in symptomatic patients aged <50 years in primary care. Rectal bleeding and change in bowel habit are strongly predictive of CRC/IBD when combined with abnormal haematology. The present findings help prioritise patients for colonoscopy where the diagnosis is not immediately apparent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.