Evidence map›Paper›PMID 28347978›Full record

ArticleBone & joint research2017

Intra-articular implantation of collagen scaffold carriers is safe in both native and arthrofibrotic rabbit knee joints.

J A Walker, T J Ewald, E Lewallen, A Van Wijnen, A D Hanssen, B F Morrey, M E Morrey, M P Abdel, J Sanchez-Sotelo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone & joint research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Biomechanical, histological, and molecular characterization of a new posttraumatic model of arthrofibrosis in rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  5. Article
  6. Reduction of arthrofibrosis utilizing a collagen membrane drug-eluting scaffold with celecoxib and subcutaneous injections with ketotifen.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020
    Article
  7. Article
  8. A Drug Eluting Scaffold for the Treatment of Arthrofibrosis.Tissue engineering. Part C, Methods · 2018
    Article
  9. Article
  10. Validation of a dynamic joint contracture measuring device in a live rabbit model of arthrofibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

J A WalkerMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
T J EwaldMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
E LewallenMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
A Van WijnenMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
A D HanssenMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
B F MorreyMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
M E MorreyMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
M P AbdelMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
J Sanchez-SoteloMayo Clinic, 200 First Street SW, Rochester, MN 55905, USA sanchezsotelo.joaquin@mayo.edu.
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSustained intra-articular delivery of pharmacological agents is an attractive modality but requires use of a safe carrier that would not induce cartilage damage or fibrosis. Collagen scaffolds are widely available and could be used intra-articularly, but no investigation has looked at the safety of collagen scaffolds within synovial joints. The aim of this study was to determine the safety of collagen scaffold implantation in a validated MATERIALS AND

methodsA total of 96 rabbits were randomly and equally assigned to four different groups: arthrotomy alone; arthrotomy and collagen scaffold placement; contracture surgery; and contracture surgery and collagen scaffold placement. Animals were killed in equal numbers at 72 hours, two weeks, eight weeks, and 24 weeks. Joint contracture was measured, and cartilage and synovial samples underwent histological analysis.

resultsAnimals that underwent arthrotomy had equivalent joint contractures regardless of scaffold implantation (-13.9°

Indexed as

ArthrofibrosisBiocompatibilityBiodegradationCollagen scaffoldKnee joint

Identifiers

PMID28347978
PMCPMC5376662
OpenAlexW2599958176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.