ArticleJournal of critical care2017
The association between sodium fluctuations and mortality in surgical patients requiring intensive care.
Article in Journal of critical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03752450 (Insight in the Development and Recovery of Hypernatremia in Critically Ill Patients.), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Insight in the Development and Recovery of Hypernatremia in Critically Ill Patients.
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Dynamic variability of serum sodium, potassium, and calcium and mortality after acute myocardial infarction: insights from traditional and machine learning approaches.BMC cardiovascular disorders · 2026Article
- Clinical outcomes associated with dynamic changes in serum sodium amongst adult patients with spontaneous subarachnoid hemorrhage and other critical illnesses: an exploratory scoping review.Critical care science · 2026Article
- Association between serum sodium trajectories and all-cause mortality in critically ill patients with ischemic stroke: a retrospective analysis of the MIMIC-IV database.European journal of medical research · 2025Article
- A Contemporary Narrative Review of Sodium Homeostasis Mechanisms, Dysnatraemia, and the Clinical Relevance in Adult Critical Illness.Journal of clinical medicine · 2025Review
- Effect of long-term serum sodium levels on the prognosis of patients on maintenance hemodialysis.Renal failure · 2024Article
- Effect of fosfomycin-induced hypernatremia on patients' hospital stay length and survival.Irish journal of medical science · 2024Article
- Association between serum sodium trajectory and mortality in patients with acute kidney injury: a retrospective cohort study.BMC nephrology · 2024Article
- CARDS, a Novel Prognostic Index for Risk Stratification and In-Hospital Monitoring.Journal of clinical medicine · 2024Article
- The association between nutritional status measured by body mass index and outcomes in the pediatric intensive care unit.Frontiers in pediatrics · 2024Article
- Observational
- Euvolaemic hyponatraemia as a rare first presentation of chronic hypopituitarism.BMJ case reports · 2023Article
- A Retrospective Cohort Study: Predicting 90-Day Mortality for ICU Trauma Patients with a Machine Learning Algorithm Using XGBoost Using MIMIC-III Database.Journal of multidisciplinary healthcare · 2023Article
- Nomogram Prediction Model of Hypernatremia on Mortality in Critically Ill Patients.Infection and drug resistance · 2023Article
- Association between serum sodium and in-hospital mortality among critically ill patients with spontaneous subarachnoid hemorrhage.Frontiers in neurology · 2022Article
- Serum sodium variability and acute kidney injury: a retrospective observational cohort study on a hospitalized population.Internal and emergency medicine · 2021Observational
- Increased mortality risk associated with serum sodium variations and borderline hypo- and hypernatremia in hospitalized adults.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Article
- Article
- A deep learning backcasting approach to the electrolyte, metabolite, and acid-base parameters that predict risk in ICU patients.PloS one · 2020Article
- Critical Care, Critical Data.Biomedical engineering and computational biology · 2019Review
- Multivariable analysis of the association between electrolyte disturbances and mortality in cats.Journal of feline medicine and surgery · 2018Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
purposeSerum sodium derangement is the most common electrolyte disturbance among patients admitted to intensive care. This study aims to validate the association between dysnatremia and serum sodium fluctuation with mortality in surgical intensive care patients.
methodWe performed a retrospective analysis of the Medical Information Mart for Intensive Care II database. Dysnatremia was defined as a sodium concentration outside physiologic range (135-145mmol/L) and subjects were categorized by severity of dysnatremia and sodium fluctuation. Univariate and multivariable logistic regressions were used to test for associations between sodium fluctuations and mortality.
resultsWe identified 8600 subjects, 39% of whom were female, with a median age of 66years for analysis. Subjects with dysnatremia were more likely to be dead at 28 days (17% vs 7%; P<.001). There was a significant association between sodium fluctuation and mortality at 28 days (adjusted odds ratio per 1mmol/L change, 1.10 [95% confidence interval, 1.08-1.12; P<.001]), even in patients who remained normotremic during their intensive care unit stay (1.12 [95% confidence interval, 1.09-1.16; P<.001])
conclusionsThis observational study validates previous findings of an association between serum sodium fluctuations and mortality in surgical intensive care patients. This association was also present in subjects who remained normonatremic throughout their intensive care unit admission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.