ArticleHeart rhythm2017
Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation.
Article in Heart rhythm, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03243448 (Using Skin Sympathetic Nerve Activity to Estimate Sympathetic Tone in Human), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Using Skin Sympathetic Nerve Activity to Estimate Sympathetic Tone in Human
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- A systematic review of the effects of transcutaneous auricular vagus nerve stimulation on baroreflex sensitivity and heart rate variability in healthy subjects.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG).Nature protocols · 2020Trial
- Using subcutaneous nerve stimulation to control atrial fibrillation.Heart rhythm O2 · 2026Article
- lncRNA-056298 Regulates GAP43 and Promotes Cardiac Intrinsic Autonomic Nerve Remodelling in a Canine Model of Atrial Fibrillation Induction after Ganglionated Plexus Ablation.Current medicinal chemistry · 2025Article
- Renal autonomic dynamics in hypertension: how can we evaluate sympathetic activity for renal denervation?Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Sympathetic toggled paroxysmal atrial fibrillation and recurrent premature atrial contractions in ambulatory patients.Heart rhythm · 2024Article
- Non-invasive Neuromodulation of Arrhythmias.Cardiac electrophysiology clinics · 2024Review
- Childhood maltreatment, genetic risk, and subsequent risk of arrhythmias: a prospective cohort study.European journal of psychotraumatology · 2024Article
- Autonomic modulation by SGLT2i or DPP4i in patients with diabetes favors cardiovascular outcomes as revealed by skin sympathetic nerve activity.Frontiers in pharmacology · 2024Article
- Autonomic Modulation of Atrial Fibrillation.JACC. Basic to translational science · 2023Review
- Sympathetic toggled sinus rate acceleration as a mechanism of sustained sinus tachycardia in chronic orthostatic intolerance syndrome.Heart rhythm · 2022Article
- Higher pre-treatment skin sympathetic nerve activity and elevated resting heart rate after chemoradiotherapy predict worse esophageal cancer outcomes.BMC cancer · 2022Observational
- Alteration of Skin Sympathetic Nerve Activity after Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation.Journal of personalized medicine · 2022Article
- Alterations of sympathetic dynamics after atrial fibrillation ablation by analysis sympathetic nerve activity provide prognostic value for recurrence and mechanistic insights into ablation.Frontiers in cardiovascular medicine · 2022Article
- The Mechanism of Cardiac Sympathetic Activity Assessment Methods: Current Knowledge.Frontiers in cardiovascular medicine · 2022Review
- Skin sympathetic nerve activity as a biomarker of fitness.Heart rhythm · 2021Article
- High Skin Sympathetic Nerve Activity in Patients with Recurrent Syncope.Journal of personalized medicine · 2021Article
- Shoulder transcutaneous electric nerve stimulation decreases heart rate via potentiating vagal tone.Scientific reports · 2021Article
- Skin sympathetic nerve activity as a biomarker for neurologic recovery during therapeutic hypothermia for cardiac arrest.Heart rhythm · 2021Observational
- Death of a child and the risk of atrial fibrillation: a nationwide cohort study in Sweden.European heart journal · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundSkin sympathetic nerve activity (SKNA) is useful for estimating sympathetic tone in humans.
objectiveThe purpose of this study was to test the hypotheses that (1) increased SKNA is associated with the onset and termination of paroxysmal atrial tachycardia (AT) and atrial fibrillation (AF) and (2) sinoatrial node response to SKNA is reduced in patients with more frequent AT or AF episodes.
methodsSKNA and electrocardiogram were recorded in 11 patients (4 men and 7 women; average age 66 ± 10 years), including 3 patients with AT (11 ± 18 episodes per patient) and 8 patients with AF (24 ± 26 episodes per patient).
resultsThe average SKNA (aSKNA) 10 seconds before AT onset was 1.07 ± 0.10 μV and 10 seconds after termination was 1.27 ± 0.10 μV; both were significantly (P = .032 and P < .0001) higher than that during sinus rhythm (0.97 ± 0.09 μV). The aSKNA 10 seconds before AF onset was 1.34 ± 0.07 μV and 10 seconds after termination was 1.31 ± 0.07 μV; both were significantly (P < .0001) higher than that during sinus rhythm (1.04 ± 0.07 μV). The aSKNA before onset (P < .0001) and after termination (P = .0011) was higher in AF than in AT. The sinus rate correlated (P < .0001) with aSKNA in each patient (average r = 0.74; 95% confidence interval 0.65-0.84). The r value in each patient negatively correlated with the number of AT and AF episodes (r = -0.6493; 95% confidence interval -0.8990 to -0.08073; P = .0306).
conclusionIncreased SKNA was observed both at the onset and termination of AT and AF. Patients with more frequent AT and AF episodes had a weak correlation between sinus rate and aSKNA, suggesting sinoatrial node remodeling by tachycardia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.