ArticleExperimental neurology2017
BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section.
Article in Experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Neutrophil responses are substantially prolonged and robust following early postnatal chorda tympani or lingual nerve transection.Experimental brain research · 2026Article
- Article
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- Interleukin (IL)-1 Receptor Signaling Is Required for Complete Taste Bud Regeneration and the Recovery of Neural Taste Responses following Axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Recovery of sweet taste preference in adult rats following bilateral chorda tympani nerve transection.PeerJ · 2022Article
- Immune responses in the injured olfactory and gustatory systems: a role in olfactory receptor neuron and taste bud regeneration?Chemical senses · 2022Review
- Whole-Mount Staining, Visualization, and Analysis of Fungiform, Circumvallate, and Palate Taste Buds.Journal of visualized experiments : JoVE · 2021Article
- Hedgehog Signaling Regulates Taste Organs and Oral Sensation: Distinctive Roles in the Epithelium, Stroma, and Innervation.International journal of molecular sciences · 2019Review
- Targeting the BDNF/TrkB pathway for the treatment of tumors.Oncology letters · 2019Review
- Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The transcription factor Phox2b distinguishes between oral and non-oral sensory neurons in the geniculate ganglion.The Journal of comparative neurology · 2017Article
- Taste bud-derived BDNF maintains innervation of a subset of TrkB-expressing gustatory nerve fibers.Molecular and cellular neurosciences · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Taste nerves readily regenerate to reinnervate denervated taste buds; however, factors required for regeneration have not yet been identified. When the chorda tympani nerve is sectioned, expression of brain-derived neurotrophic factor (BDNF) remains high in the geniculate ganglion and lingual epithelium, despite the loss of taste buds. These observations suggest that BDNF is present in the taste system after nerve section and may support taste nerve regeneration. To test this hypothesis, we inducibly deleted Bdnf during adulthood in mice. Shortly after Bdnf gene recombination, the chorda tympani nerve was unilaterally sectioned causing a loss of both taste buds and neurons, irrespective of BDNF levels. Eight weeks after nerve section, however, regeneration was differentially affected by Bdnf deletion. In control mice, there was regeneration of the chorda tympani nerve and taste buds reappeared with innervation. In contrast, few taste buds were reinnervated in mice lacking normal Bdnf expression such that taste bud number remained low. In all genotypes, taste buds that were reinnervated were normal-sized, but non-innervated taste buds remained small and atrophic. On the side of the tongue contralateral to the nerve section, taste buds for some genotypes became larger and all taste buds remained innervated. Our findings suggest that BDNF is required for nerve regeneration following gustatory nerve section.
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