ArticlePharmacology, biochemistry, and behavior2017
Sex differences in alcohol self-administration and relapse-like behavior in Long-Evans rats.
Article in Pharmacology, biochemistry, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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Who cites it
63 citing papers in PubMed, 95 citations in OpenAlex.
- Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in compulsive alcohol drinking phenotypes: implications for decision-making and social behavior in a preclinical model.Psychopharmacology · 2026Article
- Female rats are more vulnerable to binge drinking behavior in an operant self-administration paradigm: implication for transition to alcohol use disorders.Biology of sex differences · 2026Article
- Prelimbic cortex, but not its nucleus reuniens projections, regulates punished alcohol self-administration.Neuropharmacology · 2026Article
- Sex-Specific patterns of vulnerability to alcohol addiction-like behaviors in rats.Translational psychiatry · 2026Article
- COAddiction biology · 2026Article
- Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice.Alcohol (Fayetteville, N.Y.) · 2025Article
- Preconceptual paternal ethanol drinking induces sexually dimorphic behavioural changes across 2 generations.Psychopharmacology · 2025Article
- Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Individual differences in punished alcohol self-administration are unaltered by alcohol vapor exposure.Alcohol (Fayetteville, N.Y.) · 2025Observational
- Evaluating the impact of concurrent sucrose availability on operant ethanol self-administration in male and female Long Evans rats.Addiction neuroscience · 2025Article
- Operant ethanol self-administration behaviors do not predict sex differences in continuous access home cage drinking.Alcohol (Fayetteville, N.Y.) · 2025Article
- Individual and sex differences in frontloading behavior and approach- avoidance conflict preference predict addiction-like ethanol seeking in rats.Scientific reports · 2025Article
- Sex-associated differences in incentive salience and drinking behaviour in a rodent model of alcohol relapse.Addiction biology · 2025Article
- The GPR88 Agonist RTI-122 Reduces Alcohol-Related Motivation and Consumption.Addiction biology · 2025Article
- Heart rate variability: A primer for alcohol researchers.Alcohol (Fayetteville, N.Y.) · 2024Article
- Sex- and estrous-related response patterns for alcohol depend critically on the level of compulsion-like challenge.Progress in neuro-psychopharmacology & biological psychiatry · 2024Article
- Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model.Scientific reports · 2024Article
- Greater inhibition of female rat binge alcohol intake by adrenergic receptor blockers using a novel Two-Shot rat binge drinking model.Research square · 2024Article
- Validation of the extinction probe trial as a measure of motivation in male and female Long Evans rats.Alcohol, clinical & experimental research · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Alcohol use disorders are a costly public health dilemma. Complicating this issue is the general lack of basic research assessing sex differences in many aspects of alcohol seeking and taking behaviors. The current experiments sought to decrease this gap in our understanding of sex differences in alcohol use disorders by assessing both male and female Long-Evans rats in parallel on alcohol self-administration, relapse-like behavior following abstinence and extinction, and motivation to respond for the standard alcohol solution and a quinine-adulterated alcohol solution. Here, we show that while males tend to have greater alcohol-reinforced responses throughout self-administration training, females show similar or greater alcohol intake (g/kg). Additionally, when tested for reinstatement of alcohol seeking and self-administration, following abstinence or extinction, males consistently showed greater reinstatement responding than females, which may be related to their training history. However, when assessed using the progressive ratio, there were no sex differences in motivation to respond for alcohol. Further, the consistent patterns of responding across months of self-administration training in both males and females, lend support for the feasibility of conducting these studies in male and female rats in parallel without concerns about daily variability. Our data also suggest that males and females should not be pooled as differences in alcohol lever responses and differences in reinstatement, as observed in the current experiments, could affect the overall outcome and possibly confound data interpretation. These studies demonstrate the importance of assessing males and females in parallel and advance the body of preclinical research on sex differences in alcohol self-administration and relapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.