Evidence map›Paper›PMID 28347732›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Association between the p53 arginine/arginine homozygous genotype at codon 72 and human papillomavirus E6/E7 mRNA expression.

Ana Carolina Silva Chuery, Ismael Dale Cotrim Guerreiro da Silva, Julisa Chamorro Lascasas Ribalta, Neila Maria de Góis Speck

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Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. TheBiomedicines · 2023
    Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Ana Carolina Silva ChueryUniversidade Federal de São Paulo (Unifesp), Departamento de Ginecologia, Núcleo de Prevenção de Doenças Ginecológicas, São Paulo, SP, Brazil. Electronic address: acchuery@hotmail.com.
Ismael Dale Cotrim Guerreiro da SilvaUniversidade Federal de São Paulo (Unifesp), Departamento de Ginecologia, Escola Paulista de Medicina, São Paulo, SP, Brazil.
Julisa Chamorro Lascasas RibaltaUniversidade Federal de São Paulo (Unifesp), Departamento de Ginecologia, Núcleo de Prevenção de Doenças Ginecológicas, São Paulo, SP, Brazil.
Neila Maria de Góis SpeckUniversidade Federal de São Paulo (Unifesp), Departamento de Ginecologia, Núcleo de Prevenção de Doenças Ginecológicas, São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the association between p53 polymorphisms and human papillomavirus (HPV) E6/E7 mRNA expression.

methodsWe analyzed 175 cervical samples from women aged 16-69 years old who were tested for HPV E6/E7 mRNA expression (NucliSENS

resultsThe frequency of the arginine/arginine homozygous genotype at codon 72 was significantly higher in the positive (49.3%) than in the negative (32.7%) and control groups (20.8%, p=0.002*). The frequency of the arginine allele was also significantly higher in the positive (67.3%) than in the negative (53.8%) and control groups (38.5%, p<0.001*). The arginine/arginine homozygous genotype was significantly associated with positive HPV E6/E7 mRNA expression (positive group) compared with negative and control groups (odds ratio: 2.633; 95% CI, 1.399-4.954, p=0.003). The frequency of arginine/arginine homozygous genotype at codon 72 remained significantly more frequent in the positive group of women aged ≥30 years than in the other two groups.

conclusionThe presence of the p53 arginine/arginine homozygous genotype at codon 72 was significantly associated with the positive HPV E6/E7 mRNA expression.

Indexed as

AdolescentAdultAgedArginineCodonFemaleGenotypeHumansMiddle AgedOncogene Proteins, ViralPapillomaviridaePapillomavirus E7 ProteinsPapillomavirus InfectionsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthRNA, MessengerArginineCodonE6 protein, Human papillomavirus type 6Oncogene Proteins, ViralPapillomavirus E7 ProteinsRNA, MessengerRNA, ViralTP53 protein, humanTumor Suppressor Protein p53ArginineGenetic polymorphismsHuman papillomavirusOncoproteinsp53 gene

Identifiers

PMID28347732
PMCPMC9428040

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