ArticleAddiction science & clinical practice2017
The association between age of onset of opioid use and comorbidity among opioid dependent patients receiving methadone maintenance therapy.
Article in Addiction science & clinical practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- De-implementing opioid prescribing in a dental group practice: Lessons learned.Community dentistry and oral epidemiology · 2023Trial
- Barriers to progressing through a methadone maintenance treatment programme: perspectives of the clients in the Mid-West of Ireland's drug and alcohol services.BMC health services research · 2018Trial
- Persisting high rates of mental health disorders in patients in opioid agonist treatment-Results from a 6-year longitudinal study.The American journal on addictions · 2026Article
- Role of Pain in Adults Undergoing Soft Tissue and Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea.Laryngoscope investigative otolaryngology · 2025Article
- Article
- Morphine exposure during adolescence induces enduring social changes dependent on adolescent stage of exposure, sex, and social test.bioRxiv : the preprint server for biology · 2023Article
- Opioid prescriptions after knee replacement: a retrospective study of pathways and prognostic factors in the Swiss healthcare setting.BMJ open · 2023Article
- Prenatal heroin exposure alters brain morphology and connectivity in adolescent mice.NMR in biomedicine · 2023Article
- Association Between Opioid Use Disorder and Seizure Incidents Among Alcohol Use Disorder Patients.Substance abuse : research and treatment · 2023Article
- Mu Opioid Receptor Dynamics in Healthy Volunteers with a History of Childhood Maltreatment.Journal of child & adolescent trauma · 2022Article
- Telehealth-Based Delivery of Medication-Assisted Treatment for Opioid Use Disorder: a Critical Review of Recent Developments.Current psychiatry reports · 2022Review
- Psychiatric Comorbidity, Psychosocial Problems, and Functioning of People Who Inject Opioids: An Observational Study.Addiction & health · 2022Article
- Patient characteristics associated with initiation of XR-naltrexone for opioid use disorder in clinical trials.Drug and alcohol dependence · 2022Article
- The association between opioids, environmental, demographic, and socioeconomic indicators and COVID-19 mortality rates in the United States: an ecological study at the county level.Archives of public health = Archives belges de sante publique · 2021Article
- Patient, Provider Type, and Procedure Type Factors Associated with Opioid Prescribing by Dentists in a Health Care System.Journal of pain research · 2021Article
- [Aging in a methadone maintenance program. A perspective from the framework of social determinants of health].Revista espanola de salud publica · 2019Article
- Generational trends and patterns in readmission within a statewide cohort of clients receiving heroin use disorder treatment in Maryland, 2007-2013.Journal of substance abuse treatment · 2019Article
- Rapid transition from methadone to buprenorphine using naltrexone-induced withdrawal: A case report.Substance abuse · 2019Article
- Liver damage indices as a tool for modifying methadone maintenance treatment: a cross-sectional study.Croatian medical journal · 2018Article
- Pharmacological Strategies for Decreasing Opioid Therapy and Management of Side Effects from Chronic Use.Children (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundOpioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset of opioid use and comorbid disorders, both physical and psychiatric, in patients receiving methadone maintenance treatment (MMT) for OUD. Understanding this association may inform clinical practice about important prognostic factors of patients on MMT, enabling clinicians to identify high-risk patients.
methodsThis study includes data collected between June 2011 and August 2016 for the Genetics of Opioid Addiction research collaborative between McMaster University and the Canadian Addiction Treatment Centers. All patients were interviewed by trained health professionals using the Mini-International Neuropsychiatric Interview and case report forms. Physical comorbidities were verified using patients' electronic medical records. A multi-variable logistic regression model was constructed to determine the strength of the association between age of onset of opioid use and the presence of physical or psychiatric comorbidity while adjusting for current age, sex, body mass index, methadone dose and smoking status.
resultsData from 627 MMT patients with a mean age of 38.8 years (SD = 11.07) were analyzed. Individuals with an age of onset of opioid use younger than 18 years were found to be at higher odds for having a physical or psychiatric comorbid disorder compared to individuals with an age of onset of opioid use of 31 years or older (odds ratio 2.94, 95% confidence interval 1.20, 7.19, p = 0.02). A significant association was not found between the risk of having a comorbidity and an age of onset of opioid use between 18 and 25 years or 26 and 30 years, compared to an age of onset of opioid use of 31 years or older.
conclusionOur study demonstrates that the younger one begins to use opioids, the greater their chance of having a physical or psychiatric co-morbidity. Understanding the risk posed by an earlier onset of opioid use for the later development of comorbid disorders informs clinical practice about important prognostic predictors and aids in the identification of high-risk patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.