Evidence map›Paper›PMID 28347335›Full record

ArticleBMC biology2017

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H

Eduardo Pinho Melo, Carlos Lopes, Peter Gollwitzer, Stephan Lortz, Sigurd Lenzen, Ilir Mehmeti, Clemens F Kaminski, David Ron, Edward Avezov

Open access · goldAbstract read
In one paragraph

Article in BMC biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. The Passage of HPlants (Basel, Switzerland) · 2022
    Review
  5. Review
  6. Review
  7. In Vivo Imaging with Genetically Encoded Redox Biosensors.International journal of molecular sciences · 2020
    Review
  8. Review
  9. Article
  10. Review
  11. CaBMC biology · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Eduardo Pinho MeloUniversity of Cambridge, Cambridge Institute for Medical Research, the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.
Carlos LopesCentre for Biomedical Research, Universidade do Algarve, Faro, Portugal.
Peter GollwitzerUniversity of Cambridge, Cambridge Institute for Medical Research, the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.
Stephan LortzInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, 30625, Germany.
Sigurd LenzenInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, 30625, Germany.
Ilir MehmetiInstitute of Clinical Biochemistry, Hannover Medical School, Hannover, 30625, Germany.
Clemens F KaminskiDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, CB2 3RA, UK.
David RonUniversity of Cambridge, Cambridge Institute for Medical Research, the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK. dr360@medschl.cam.ac.uk.
Edward AvezovUniversity of Cambridge, Cambridge Institute for Medical Research, the Wellcome Trust MRC Institute of Metabolic Science and NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK. ea347@cam.ac.uk.ORCID 0000-0002-2894-0585
Medizinische Hochschule Hannover · DEUniversity of Cambridge · GBWellcome/MRC Cambridge Stem Cell Institute · GBAlgarve Biomedical Center · PT

Funding

Biotechnology and Biological Sciences Research Council BB/H023917/1Medical Research Council G0902243Medical Research Council MR/K015850/1Medical Research Council MR/K02292X/1Wellcome Trust 200848/Z/16/Z
6 · The paper itself

Abstract

backgroundThe fate of hydrogen peroxide (H

resultsHere we report on the development of TriPer, a vital optical probe sensitive to changes in the concentration of H

conclusionsA tri-cysteine system with a single peroxidatic thiol enables H

Indexed as

Optical PhenomenaAnimalsCatalysisCell LineEndoplasmic ReticulumFluorescenceGlutathioneHumansHydrogen PeroxideInsulin-Secreting CellsKineticsMiceMolecular ProbesOxidation-ReductionSulfhydryl CompoundsGlutathioneHydrogen PeroxideMolecular ProbesSulfhydryl CompoundsEndoplasmic reticulumFluorescence lifetime imagingFluorescent protein sensorGlutathioneH2O2 probeHydrogen peroxideLive cell imagingPancreatic β-cellsRedox

Identifiers

PMID28347335
PMCPMC5368998
OpenAlexW2603730074

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.