Evidence map›Paper›PMID 28347310›Full record

ArticleMalaria journal2017

A novel in vitro model reveals distinctive modulatory roles of Plasmodium falciparum and Plasmodium vivax on naïve cell-mediated immunity.

Setthakit Chitsanoor, Sangdao Somsri, Panyu Panburana, Mathirut Mungthin, Ratawan Ubalee, Maliwan Emyeam, Somchai Jongwutiwes, Jetsumon Sattabongkot, Rachanee Udomsangpetch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Setthakit ChitsanoorDepartment of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Sangdao SomsriGraduate Programme in Biomedical Science, Faculty of Allied Health Sciences, Thammasart University, Pathumthani, Thailand.
Panyu PanburanaDepartment of Obstetrics and Gynecology, Faculty of Medicine Ramathibodhi Hospital, Mahidol University, Bangkok, Thailand.
Mathirut MungthinDepartment of Parasitology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand.
Ratawan UbaleeDepartment of Entomology, USAMC Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
Maliwan EmyeamDepartment of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Somchai JongwutiwesMolecular Biology of Malaria and Opportunistic Parasites Research Unit, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jetsumon SattabongkotMahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Rachanee UdomsangpetchCenters for Emerging and Neglected Infectious Diseases, Mahidol University, Bangkok, Thailand. rachanee.udo@mahidol.ac.th.ORCID 0000-0003-4780-4914
Mahidol University · THArmed Forces Research Institute of Medical Science · THChulalongkorn University · THPhramongkutklao Hospital · THThammasat University · TH

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundTo date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and cross reactivity with other infectious agents. Resolving these limitations requires an alternative in vitro model to uncover the primary response profiles.

methodsA novel in vitro model of mononuclear cells (MNCs) generated from haematopoietic stem cells (HSCs) was developed and these cells were then co-cultured with various antigens from Plasmodium falciparum and Plasmodium vivax to investigate the response of naïve immune cells to malaria antigens by flow cytometry.

resultsIn vitro stimulation of naïve lymphocytes showed that CD4

conclusionThese results suggest that naïve mononuclear cells differentiated in vitro from HSCs could provide a valid model for the assessment of immunity. P. falciparum and P. vivax malaria parasites could modulate various populations of immune cells starting from newly differentiated mononuclear cells.

Indexed as

Immunity, CellularHematopoietic Stem CellsHumansLeukocytes, MononuclearMalaria, FalciparumMalaria, VivaxPlasmodium falciparumPlasmodium vivaxCell mediated immunityHematopoietic stem cellsMalaria

Identifiers

PMID28347310
PMCPMC5368906
OpenAlexW2602991341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.