ArticleNanomaterials (Basel, Switzerland)2015
Cytotoxicity, Uptake Behaviors, and Oral Absorption of Food Grade Calcium Carbonate Nanomaterials.
Article in Nanomaterials (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Preparation of Lake Pigment from Calcium Carbonate and Cyanidin-3-O-Glucoside: Structural Characterization and Formation Mechanism.Foods (Basel, Switzerland) · 2026Article
- Occupational Exposure to UPVC Powder Containing Calcium Carbonate (CaCOHealth science reports · 2026Article
- Enhanced oral nanomedicine utilizing biomineralized oncolytic virus for synergistic gastrointestinal cancer therapy.Materials today. Bio · 2025Article
- Formation Mechanisms of Protein Coronas on Food-Related Nanoparticles: Their Impact on Digestive System and Bioactive Compound Delivery.Foods (Basel, Switzerland) · 2025Review
- Influence of the Crystal Forms of Calcium Carbonate on the Preparation and Characteristics of Indigo Carmine-Calcium Carbonate Lake.Foods (Basel, Switzerland) · 2024Article
- Preparation of Edible Colorant Lake Using Calcium Carbonate and β-Carotene: Structural Characterization and Formation Mechanism Study.Foods (Basel, Switzerland) · 2024Article
- Determinants and mechanisms of inorganic nanoparticle translocation across mammalian biological barriers.Archives of toxicology · 2023Review
- Preliminary Study on the Preparation of Conductive Nanosized Calcium Carbonate Utilizing Biogas Slurry by a Synchronous Double Decomposition Coating Method.Nanomaterials (Basel, Switzerland) · 2023Article
- Nano Functional Food: Opportunities, Development, and Future Perspectives.International journal of molecular sciences · 2022Review
- Photochemical Consideration in the Interactions between Blood Proteins and Layered Inorganic Materials.International journal of molecular sciences · 2022Article
- Development of Nano Soy Milk through Sensory Attributes and Consumer Acceptability.Foods (Basel, Switzerland) · 2021Article
- Synthesis and Characterization of Gefitinib and Paclitaxel Mono and Dual Drug-Loaded Blood Cockle Shells (Nanomaterials (Basel, Switzerland) · 2021Article
- Current Nanocarrier Strategies Improve Vitamin B12 Pharmacokinetics, Ameliorate Patients' Lives, and Reduce Costs.Nanomaterials (Basel, Switzerland) · 2021Review
- Fabrication and Impact of Fouling-Reducing Temperature-Responsive POEGMA Coatings with Embedded CaCOMaterials (Basel, Switzerland) · 2021Article
- A Brief Review about the Role of Nanomaterials, Mineral-Organic Nanoparticles, and Extra-Bone Calcification in Promoting Carcinogenesis and Tumor Progression.Biomedicines · 2019Review
- Calcium Carbonate Nanoparticles Can Activate the Epithelial⁻Mesenchymal Transition in an Experimental Gastric Cancer Model.Biomedicines · 2019Article
- Titanium Dioxide Nanoparticle-Biomolecule Interactions Influence Oral Absorption.Nanomaterials (Basel, Switzerland) · 2016Article
- Nanotechnology in food science: Functionality, applicability, and safety assessment.Journal of food and drug analysis · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium is the most abundant mineral in human body and essential for the formation and maintenance of bones and teeth as well as diverse cellular functions. Calcium carbonate (CaCO₃) is widely used as a dietary supplement; however, oral absorption efficiency of CaCO₃ is extremely low, which may be overcome by applying nano-sized materials. In this study, we evaluated the efficacy of food grade nano CaCO₃ in comparison with that of bulk- or reagent grade nano CaCO₃ in terms of cytotoxicity, cellular uptake, intestinal transport, and oral absorption. Cytotoxicity results demonstrated that nano-sized CaCO₃ particles were slightly more toxic than bulk materials in terms of oxidative stress and membrane damage. Cellular uptake behaviors of CaCO₃ nanoparticles were different from bulk CaCO₃ or Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.