Evidence map›Paper›PMID 28346998›Full record

ArticleNanomaterials (Basel, Switzerland)2014

Cellular Uptake of Tile-Assembled DNA Nanotubes.

Samet Kocabey, Hanna Meinl, Iain S MacPherson, Valentina Cassinelli, Antonio Manetto, Simon Rothenfusser, Tim Liedl, Felix S Lichtenegger

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Functionalizing DNA nanostructures for therapeutic applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021
    Review
  7. Membrane-Interacting DNA Nanotubes Induce Cancer Cell Death.Nanomaterials (Basel, Switzerland) · 2021
    Article
  8. Article
  9. Review
  10. Challenges and Perspectives of DNA Nanostructures in Biomedicine.Angewandte Chemie (International ed. in English) · 2020
    Review
  11. Article
  12. Unprecedently high targeting specificity toward lung ICAM-1 using 3DNA nanocarriers.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Article
  13. Review
  14. DNA nanostructures coordinate gene silencing in mature plants.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  15. Article
  16. MgJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samet KocabeyFaculty of Physics and Center for Nanoscience, Ludwig-Maximilians University, Munich 80799, Germany. samet.kocabey@physik.lmu.de.
Hanna MeinlDivision of Clinical Pharmacology, Department of Internal Medicine IV, Klinikum der Universität München, Munich 80336, Germany. hanna.meinl@outlook.com.
Iain S MacPhersonFaculty of Physics and Center for Nanoscience, Ludwig-Maximilians University, Munich 80799, Germany. iainmacpherson@gmail.com.
Valentina CassinelliBaseclick GmbH, Tutzing 82327, Germany. v.cassinelli@baseclick.eu.
Antonio ManettoBaseclick GmbH, Tutzing 82327, Germany. a.manetto@baseclick.eu.
Simon RothenfusserDivision of Clinical Pharmacology, Department of Internal Medicine IV, Klinikum der Universität München, Munich 80336, Germany. simon.rothenfusser@med.uni-muenchen.de.
Tim LiedlFaculty of Physics and Center for Nanoscience, Ludwig-Maximilians University, Munich 80799, Germany. tim.liedl@physik.lmu.de.
Felix S LichteneggerDivision of Clinical Pharmacology, Department of Internal Medicine IV, Klinikum der Universität München, Munich 80336, Germany. felix.lichtenegger@med.uni-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA-based nanostructures have received great attention as molecular vehicles for cellular delivery of biomolecules and cancer drugs. Here, we report on the cellular uptake of tubule-like DNA tile-assembled nanostructures 27 nm in length and 8 nm in diameter that carry siRNA molecules, folic acid and fluorescent dyes. In our observations, the DNA structures are delivered to the endosome and do not reach the cytosol of the

Indexed as

cationDNA nanotechnologyDNA tilefolatesiRNA deliverystability

Identifiers

PMID28346998
PMCPMC5312849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.