ReviewNestle Nutrition Institute workshop series2017
Differential Establishment of Bifidobacteria in the Breastfed Infant Gut.
Review in Nestle Nutrition Institute workshop series, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04662619 (A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled, Two-Arm, Parallel-Group, Nutritional Intervention Study to Examine the Clinical and Immunological Effects of a Probiotic Food Supplement Containing B. Infantis), which is not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled, Two-Arm, Parallel-Group, Nutritional Intervention Study to Examine the Clinical and Immunological Effects of a Probiotic Food Supplement Containing B. Infantis (EVC001) in Healthy Breastfed Infants at Risk of Developing Atopic Dermatitis
Who cites it
36 citing papers in PubMed.
- Trial
- Analysis of immune, microbiota and metabolome maturation in infants in a clinical trial of Lactobacillus paracasei CBA L74-fermented formula.Nature communications · 2020Trial
- Neonatal Vitamin A Supplementation and Vitamin A Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age.The Journal of nutrition · 2019Trial
- Trial
- Effects of Breast Milk or Supplemented Formula Milk on Fecal Metabolomic Profile.Current pediatric reviews · 2026Review
- Sampling frequency matters: mapping of the healthy infants' gut microbiome during the first year of life.Current research in microbial sciences · 2025Article
- Mitigating Intestinal Dysbiosis in the Very Preterm Infant.Advances in nutrition (Bethesda, Md.) · 2024Article
- Characterising glycosaminoglycans in human breastmilk and their potential role in infant health.Microbial cell (Graz, Austria) · 2024Article
- Microbiota, metabolic profiles and immune biomarkers in infants receiving formula with added bovine milk fat globule membrane: a randomized, controlled trial.Frontiers in nutrition · 2024Article
- Changes in Gut Microbiota at 1-60 Days in 92 Preterm Infants in a Neonatal Intensive Care Unit Using 16S rRNA Gene Sequencing.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Review and Perspectives onMicroorganisms · 2023Review
- Biological Relevance of Goat Milk Oligosaccharides to Infant Health.Journal of agricultural and food chemistry · 2023Review
- Interspecies Interactions within the Host: the Social Network of Group BInfection and immunity · 2023Review
- Conversations in the Gut: The Role of Quorum Sensing in Normobiosis.International journal of molecular sciences · 2023Review
- Potential Pathogenic and Opportunistic Oral Bacteria in Early Life: The Role of Maternal Factors in a Portuguese Population.Pathogens (Basel, Switzerland) · 2023Article
- Role of human milk oligosaccharide metabolizing bacteria in the development of atopic dermatitis/eczema.Frontiers in pediatrics · 2023Review
- Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides.The ISME journal · 2022Article
- Why Are Bifidobacteria Important for Infants?Microorganisms · 2022Review
- Role of Bifidobacteria on Infant Health.Microorganisms · 2021Review
- Captive Common Marmosets (Callithrix jacchus) Are Colonized throughout Their Lives by a Community ofmBio · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The composition of an infant's gut microbiome can impact their immediate and long-term health. Bifdobacteria play a major role in structuring the gut microbiome of breastfed infants due to their ability to consume oligosaccharides found in human milk. However, recent studies have revealed that bifidobacteria are often absent in the gut microbiome of breastfed infants in some locations. This lack of colonization may be due either to differences in the environmental conditions in the gastrointestinal tract of uncolonized infants which prohibit the growth of bifidobacteria or a dearth of sources from which infants may acquire these specialized bacterial species. Potential mechanisms by which these broad factors may lead to lower colonization of infants by bifidobacteria are discussed herein. Environmental conditions which may select against bifidobacteria include low rates/duration of breastfeeding, milk glycan composition, and antimicrobial use. Routes of colonization by bifidobacteria which may be disrupted include maternal transfer via vaginal birth, fecal-oral routes, or via breast milk itself. A careful contemplation of the conditions experienced by bifidobacteria over human evolutionary history may lead to further hypotheses as to the causative factors of the differential colonization by this foundation genus in some contemporary locations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.