ArticleVeterinary clinical pathology2017
Age-related variation in the cellular composition of equine bronchoalveolar lavage fluid.
Article in Veterinary clinical pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Protective immune response against Rhodococcus equi: An innate immunity-focused review.Equine veterinary journal · 2025Review
- Effect of age, season, and gender on bronchoalveolar lavage fluid cytology in camels.Open veterinary journal · 2023Article
- Comparison of the broncoalveolar lavage fluid proteomics between foals and adult horses.PloS one · 2023Article
- Immune cell composition of the bronchoalveolar lavage fluid in healthy and respiratory diseased dromedary camels.BMC veterinary research · 2022Article
- Flow Cytometric Analysis of Leukocyte Populations in the Lung Tissue of Dromedary Camels.Veterinary sciences · 2022Article
- Host-directed therapy in foals can enhance functional innate immunity and reduce severity of Rhodococcus equi pneumonia.Scientific reports · 2021Article
- Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006-2016).Journal of veterinary internal medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPrevious reports reveal variation in the cellular composition of equine bronchoalveolar lavage fluid (BALF).
objectivesThe purpose of this study was to compare the profiles of BALF from horses to assess age-related differences. Serial BALF samples were collected from the same individuals over a one-year period to identify changes in individual animals as they aged.
methodsCollection of BALF was performed on horses aged one week and one, 2, 6, and 12 months. Total nucleated cell count (TNCC), protein concentration, and cytology were assessed. Longitudinal analysis was performed and compared to healthy adults.
resultsFoals at one week and 6 months of age had significantly higher TNCC than adults (medians: 320/μL, 285/μL, and 90/μL, respectively); no differences in total protein were found. Foals at one month had the highest proportion of macrophages (median: 87.3%), differing significantly from both yearlings and adults (medians: 45.5% and 48.7%, respectively). Foals aged one week and one month had significantly lower proportions of lymphocytes than yearlings and adults (medians: 3.2% and 4.7% vs 43.2% and 45.8%, respectively). Eosinophil percentage was lowest in foals aged one week, one month, and 2 months (median: 0.0%) and highest in foals aged 6 months (median: 2.2%). Mast cell percentages were highest in yearlings and adults (medians: 2.2% and 3.3%, respectively) and neutrophil percentage was highest in foals aged one week (13.7%).
conclusionsCytologic profiles of BALF from foals and adult horses differed considerably. Significant changes in TNCC and percentages of lymphocytes, macrophages, and eosinophils occurred with age.
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