Evidence map›Paper›PMID 28346567›Full record

Trial reportThe journal of nutrition, health & aging2017

Effect of a Low Glycemic Index Mediterranean Diet on Non-Alcoholic Fatty Liver Disease. A Randomized Controlled Clinici Trial.

G Misciagna, M Del Pilar Díaz, D V Caramia, C Bonfiglio, I Franco, M R Noviello, M Chiloiro, D I Abbrescia, A Mirizzi, M Tanzi and 6 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of nutrition, health & aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06186869 (Effects of Two Different Exercise Programs Combined With the Mediterranean Diet on Inflammatory Status in Subjects With Obesity and NAFLD), which is not on this map. Cited by 64 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 13 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06186869 narecruitingnot on this mapstarted 2023, after this paper: background citation

Effects of Two Different Exercise Programs Combined With the Mediterranean Diet on Inflammatory Status in Subjects With Obesity and NAFLD

TypeinterventionalSponsorAzienda Ospedaliera Specializzata in Gastroenterologia Saverio de BellisRan2023 to 2026Enrolled90ConditionsObesity, NAFLDArmsAerobic Exercise and diet intervention, Hiit and diet intervention, Diet
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 13 syntheses or guidelines pooled it, 130 citations in OpenAlex.

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  9. Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020
    Pooled it
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  12. ESPEN guideline on clinical nutrition in liver disease.Clinical nutrition (Edinburgh, Scotland) · 2019
    Guideline
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

G MisciagnaAlberto Rubén Osella, PhD, Laboratory of Epidemiology and Biostatistics, IRCCS Saverio de Bellis, Via Turi 27, 70013 Castellana Grotte (BA), Italy, Tel: +39 0804994655, Fax: +39 0804994650, e-mail: arosella@irccsdebellis.it.
M Del Pilar Díaz
D V Caramia
C Bonfiglio
I Franco
M R Noviello
M Chiloiro
D I Abbrescia
A Mirizzi
M Tanzi
M G Caruso
M Correale
R Reddavide
R Inguaggiato
A M Cisternino
A R Osella
Gastroenterology Hospital "Saverio de Bellis" · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNon-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS).

designNUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14. SETTING/

participants98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD.

interventionThe intervention strategy was the assignment of a LGIMD or a control diet. OUTCOME MEASURES: The main outcome measure was NAFLD score, defined by LUS.

resultsAfter randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed.

conclusionsLGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease.

Indexed as

Diet, MediterraneanAdultAgedBlood GlucoseBlood PressureBody HeightBody WeightDiabetes Mellitus, Type 2Double-Blind MethodFemaleGlycemic IndexHumansInsulinItalyLife StyleMaleBlood GlucoseInsulinHepatic steatosislow glycemic index Mediterranean dietMediterranean diet

Identifiers

PMID28346567
PMCPMC12879795
OpenAlexW2525061232

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.