ArticleNature nanotechnology2017
Confined space facilitates G-quadruplex formation.
Article in Nature nanotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The trial behind it
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Who cites it
32 citing papers in PubMed.
- Single-molecule mechanostructural fingerprinting of nucleic acid conformations.Nucleic acids research · 2026Article
- Controlled Nanoconfinement in a Microfluidic Modular Bead Array Device via Elastomeric Diaphragm Collapse for Enhancing Biomolecular Binding Kinetics.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- G-quadruplex topologies determine the functional outcome of guanine-rich bioactive oligonucleotides.Nucleic acids research · 2025Article
- Spotlight on G-Quadruplexes: From Structure and Modulation to Physiological and Pathological Roles.International journal of molecular sciences · 2024Review
- G-Quadruplexes in Human Telomere: Structures, Properties, and Applications.Molecules (Basel, Switzerland) · 2023Review
- Mapping Single-Molecule Protein Complexes in 3D with DNA Nanoswitch Calipers.Journal of the American Chemical Society · 2023Article
- Mitochondria and G-quadruplex evolution: an intertwined relationship.Trends in genetics : TIG · 2023Review
- Article
- Zeptoliter DNA Origami Reactor to Reveal Cosolute Effects on Nanoconfined G-Quadruplexes.The journal of physical chemistry letters · 2022Article
- Article
- Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity.Nucleic acids research · 2022Article
- G-Quadruplexes in Neurobiology and Virology: Functional Roles and Potential Therapeutic Approaches.JACS Au · 2021Review
- A Novel DNAzyme Signal Amplification-based Colorimetric Method for RNase H Assays.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021Article
- DNA origami nano-mechanics.Chemical Society reviews · 2021Review
- Characterization of G-Quadruplexes Folding/Unfolding Dynamics and Interactions with Proteins from Single-Molecule Force Spectroscopy.Biomolecules · 2021Review
- Dynamics of TRF1 organizing a single human telomere.Nucleic acids research · 2021Article
- Insights into the Structure and Energy of DNA Nanoassemblies.Molecules (Basel, Switzerland) · 2020Review
- The regulation and functions of DNA and RNA G-quadruplexes.Nature reviews. Molecular cell biology · 2020Review
- Label-free single-molecule identification of telomere G-quadruplexes with a solid-state nanopore sensor.RSC advances · 2020Article
- Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro.Nucleic acids research · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular simulations suggest that the stability of a folded macromolecule increases in a confined space due to entropic effects. However, due to the interactions between the confined molecular structure and the walls of the container, clear-cut experimental evidence for this prediction is lacking. Here, using DNA origami nanocages, we show the pure effect of confined space on the property of individual human telomeric DNA G-quadruplexes. We induce targeted mechanical unfolding of the G-quadruplex while leaving the nanocage unperturbed. We find that the mechanical and thermodynamic stabilities of the G-quadruplex inside the nanocage increase with decreasing cage size. Compared to the case of diluted or molecularly crowded buffer solutions, the G-quadruplex inside the nanocage is significantly more stable, showing a 100 times faster folding rate. Our findings suggest the possibility of co-replicational or co-transcriptional folding of G-quadruplex inside the polymerase machinery in cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.